Breast Cancer Research

Articles Available on Medscape

• Regular Use of Aspirin and Other Non-Steroidal Anti-inflammatory Drugs and Breast Cancer Risk for Women at Familial or Genetic Risk
  Do ASA and COX-2 inhibitors reduce risk of breast cancer in BRCA mutation carriers?

  June 10, 2019

• Prognostic and Predictive Value of Androgen Receptor Expression in Postmenopausal Women With Estrogen Receptor-Positive Breast Cancer
  Does androgen receptor expression predict response to tamoxifen in women with ER+ breast cancers?

  May 10, 2019

• A Potential Therapeutic Target for Triple-Negative Breast Cancer
  Metformin, fluoxetine, and other AMPK agonists significantly inhibit TNBC. Will targeted therapy finally become an option for this aggressive disease?

  April 26, 2019

• Associations Between Dietary Patterns and the Risk of Breast Cancer
  A diet high in red meat and high-fat dairy products may be associated with an increased risk of breast cancer.

  April 12, 2019

• Adipocytes Promote Breast Cancer Resistance to Chemotherapy, a Process Amplified by Obesity
  Adipocytes may play a role in resistance to doxorubicin. Could this be one reason why obesity is associated with chemoresistance?

  March 29, 2019

Table of Contents

2019 - 21 (1)

• Machine learning techniques for personalized breast cancer risk prediction: comparison with the BCRAT and BOADICEA models. 

  June 20, 2019

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• The p52 isoform of SHC1 is a key driver of breast cancer initiation. 

  June 15, 2019

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• On-treatment biomarkers can improve prediction of response to neoadjuvant chemotherapy in breast cancer. 

  June 14, 2019

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• Reanalysis of the NCCN PD-L1 companion diagnostic assay study for lung cancer in the context of PD-L1 expression findings in triple-negative breast cancer. 

  June 13, 2019

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• Clinical outcomes after palbociclib with or without endocrine therapy in postmenopausal women with hormone receptor positive and HER2-negative metastatic breast cancer enrolled in the TREnd trial. 

  May 29, 2019

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• Association between C-reactive protein and radiotherapy-related pain in a tri-racial/ethnic population of breast cancer patients: a prospective cohort study. 

  May 28, 2019

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• Nintedanib plus letrozole in early breast cancer: a phase 0/I pharmacodynamic, pharmacokinetic, and safety clinical trial of combined FGFR1 and aromatase inhibition. 

  May 24, 2019

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• Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk. 

  May 22, 2019

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• Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models. 

  May 22, 2019

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• Rack1 mediates tyrosine phosphorylation of Anxa2 by Src and promotes invasion and metastasis in drug-resistant breast cancer cells. 

  May 22, 2019

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• Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies. 

  May 17, 2019

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• Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications. 

  May 17, 2019

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• Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo. 

  May 17, 2019

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• Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization. 

  May 17, 2019

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• Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer. 

  May 14, 2019

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• Development of central nervous system metastases as a first site of metastatic disease in breast cancer patients treated in the neoadjuvant trials GeparQuinto and GeparSixto. 

  May 10, 2019

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• Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years. 

  May 06, 2019

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• Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer. 

  May 06, 2019

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• Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2. 

  May 02, 2019

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• Distant metastasis dynamics following subsequent surgeries after primary breast cancer removal. 

  May 02, 2019

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• The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer. 

  April 29, 2019

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• Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer. 

  April 29, 2019

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• The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells. 

  April 24, 2019

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• Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study. 

  April 18, 2019

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• BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells. 

  April 17, 2019

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• Association between prediagnostic leukocyte telomere length and breast cancer risk: the Singapore Chinese Health Study. 

  April 17, 2019

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• The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1. 

  April 03, 2019

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• Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype. 

  April 03, 2019

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• CD68, CD163, and matrix metalloproteinase 9 (MMP-9) in breast tumor microenvironment to predict breast cancer survival: are they enough? 

  April 03, 2019

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• Genomic signature of parity in the breast of premenopausal women. 

  March 28, 2019

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• Correction to: ECM1 regulates cell proliferation and trastuzumab resistance through activation of EGF-signaling. 

  March 26, 2019

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• Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study. 

  March 22, 2019

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• Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer. 

  March 21, 2019

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• Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model. 

  March 19, 2019

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• A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling. 

  January 31, 2019

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• Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR). 

  January 31, 2019

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• Serum erythropoietin levels, breast cancer and breast cancer-initiating cells. 

  January 30, 2019

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• Letter to the Editor: A response to Hruska's case study on molecular breast imaging and the need for true tissue quantification. 

  January 29, 2019

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• Associations between dietary patterns and the risk of breast cancer: a systematic review and meta-analysis of observational studies. 

  January 29, 2019

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• The long-term prognostic and predictive capacity of cyclin D1 gene amplification in 2305 breast tumours. 

  January 28, 2019

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• The distribution and determinants of mammographic density measures in Western Australian aboriginal women. 

  January 28, 2019

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• Patterns of occurrence and implications of neratinib-associated diarrhea in patients with HER2-positive breast cancer: analyses from the randomized phase III ExteNET trial. 

  January 27, 2019

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• Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment. 

  January 27, 2019

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• Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier. 

  January 25, 2019

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• p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling. 

  January 25, 2019

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• Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer. 

  January 24, 2019

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• Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer. 

  January 23, 2019

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• Prognostic and predictive value of androgen receptor expression in postmenopausal women with estrogen receptor-positive breast cancer: results from the Breast International Group Trial 1-98. 

  January 22, 2019

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• Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study. 

  January 22, 2019

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• Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model. 

  January 22, 2019

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• HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer. 

  January 22, 2019

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• AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer. 

  January 21, 2019

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• Infiltrating stromal immune cells in inflammatory breast cancer are associated with an improved outcome and increased PD-L1 expression. 

  January 18, 2019

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• MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer. 

  January 18, 2019

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• Correction to: Targeted therapy against Bcl-2-related proteins in breast cancer cells. 

  January 17, 2019

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• Adipocytes promote breast cancer resistance to chemotherapy, a process amplified by obesity: role of the major vault protein (MVP). 

  January 17, 2019

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• Hydrodynamic shear stress promotes epithelial-mesenchymal transition by downregulating ERK and GSK3β activities. 

  January 16, 2019

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• Imprint of parity and age at first pregnancy on the genomic landscape of subsequent breast cancer. 

  January 15, 2019

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• Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain. 

  January 14, 2019

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• Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas. 

  January 14, 2019

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• Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells. 

  January 14, 2019

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• Impact of obesity on breast cancer recurrence and minimal residual disease. 

  January 13, 2019

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• Airborne metals and polycyclic aromatic hydrocarbons in relation to mammographic breast density. 

  January 13, 2019

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• Parity, breastfeeding, and breast cancer risk by hormone receptor status and molecular phenotype: results from the Nurses' Health Studies. 

  January 12, 2019

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• CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB. 

  January 12, 2019

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• PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial. 

  January 11, 2019

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• Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. 

  January 08, 2019

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• Targeted mutation detection in breast cancer using MammaSeq™. 

  January 08, 2019

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• GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. 

  January 07, 2019

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• Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours. 

  January 07, 2019

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• Separation of breast cancer and organ microenvironment transcriptomes in metastases. 

  January 06, 2019

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• Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy. 

  January 06, 2019

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• A method of producing genetically manipulated mouse mammary gland. 

  January 05, 2019

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• Updating the role of obesity and cholesterol in breast cancer. 

  January 01, 2019

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• MiR-1287-5p inhibits triple negative breast cancer growth by interaction with phosphoinositide 3-kinase CB, thereby sensitizing cells for PI3Kinase inhibitors. 

  January 01, 2019

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