Laboratory Investigation

Articles Available on Medscape

• Distinctive Properties of Plaque-Type Dura Mater Graft-Associated Creutzfeldt-Jakob Disease in Cell-protein Misfolding Cyclic Amplification
  In this paper, the authors introduce a new method for identifying iatrogenic Creutzfeldt-Jakob disease using protein misfolding cyclic amplification.

  July 06, 2016

• Prolyl Isomerase Pin1 Promotes Survival in EGFR-Mutant Lung Adenocarcinoma Cells With an Epithelial-Mesenchymal Transition Phenotype
  The findings of this study suggest that inhibition of Pin1 activity could be a novel strategy for lung cancer treatment.

  May 13, 2016

• Loss of Antigenicity With Tissue Age in Breast Cancer
  Breast cancer specimens are often archived for many years for research or follow-up purposes. Do expression and detection of target biomarkers degrade over time in FFPE tissues?

  April 13, 2016

• WNT Signaling in Glioblastoma and Therapeutic Opportunities
  WNT signaling plays a crucial role in both CNS development and cancer. Could targeting WNT signaling be a viable therapeutic approach for glioblastoma?

  March 03, 2016

• Attenuation of Methylglyoxal-Induced Peritoneal Fibrosis: Immunomodulation by Interleukin-10
  Might immunomodulation with interleukin-10 offer an effective therapeutic strategy for prevention or treatment of peritoneal fibrosis, a complication of peritoneal dialysis?

  February 18, 2016

Table of Contents

2018 -

• The cofilin phosphatase slingshot homolog 1 restrains angiotensin II-induced vascular hypertrophy and fibrosis in vivo. 

  October 05, 2018

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• First trimester placental endothelial cells from pregnancies with abnormal uterine artery Doppler are more sensitive to apoptotic stimuli. 

  October 05, 2018

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• Mitochondrial pyruvate carrier 1 functions as a tumor suppressor and predicts the prognosis of human renal cell carcinoma. 

  October 05, 2018

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• Activation of brown adipose tissue enhances the efficacy of caloric restriction for treatment of nonalcoholic steatohepatitis. 

  September 26, 2018

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• Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma. 

  September 25, 2018

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• Overexpression of KLF14 protects against immune-mediated hepatic injury in mice. 

  September 25, 2018

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• Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21. 

  September 20, 2018

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• Western-type diet differentially modulates osteoblast, osteoclast, and lipoblast differentiation and activation in a background of APOE deficiency. 

  September 11, 2018

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• Application of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma. 

  September 11, 2018

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• The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis. 

  September 11, 2018

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• Trends in the characteristics of human functional genomic data on the gene expression omnibus, 2001-2017. 

  September 11, 2018

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• Vitamin D protects human melanocytes against oxidative damage by activation of Wnt/β-catenin signaling. 

  September 11, 2018

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• Enediyne-activated, EGFR-targeted human β-defensin 1 has therapeutic efficacy against non-small cell lung carcinoma. 

  September 11, 2018

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• Ki67 reproducibility using digital image analysis: an inter-platform and inter-operator study. 

  September 04, 2018

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• The oncogenic RNA-binding protein SRSF1 regulates LIG1 in non-small cell lung cancer. 

  September 04, 2018

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• An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues. 

  September 03, 2018

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• Endogenous and exogenous galectin-3 promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulation of N-cadherin and CD44. 

  August 31, 2018

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• Ursodeoxycholate inhibits mast cell activation and reverses biliary injury and fibrosis in Mdr2-/- mice and human primary sclerosing cholangitis. 

  August 24, 2018

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• Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic steatosis, inflammation, and fibrosis. 

  August 08, 2018

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• The direct binding of collagen XVII and collagen IV is disrupted by pemphigoid autoantibodies. 

  August 08, 2018

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• The effect of mesenchymal stem cells' secretome on lung cancer progression is contingent on their origin: primary or metastatic niche. 

  August 08, 2018

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• Wild-type p53-modulated autophagy and autophagic fibroblast apoptosis inhibit hypertrophic scar formation. 

  August 08, 2018

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• Genome-wide DNA methylation encodes cardiac transcriptional reprogramming in human ischemic heart failure. 

  August 08, 2018

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• Remifentanil upregulates hepatic IL-18 binding protein (IL-18BP) expression through transcriptional control. 

  August 08, 2018

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• PHF20L1 antagonizes SOX2 proteolysis triggered by the MLL1/WDR5 complexes. 

  August 08, 2018

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• Interferon-γ mediates the protective effects of soluble receptor for advanced glycation end-product in myocardial ischemia/reperfusion. 

  August 08, 2018

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• Characterizing well-differentiated culture of primary human nasal epithelial cells for use in wound healing assays. 

  August 08, 2018

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• Enzyme-free digital counting of endogenous circular RNA molecules in B-cell malignancies. 

  August 07, 2018

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• Lipocalin-2 abrogates epithelial cell cycle arrest by PPARγ inhibition. 

  August 07, 2018

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• Novel cell enrichment technique for robust genetic analysis of archival classical Hodgkin lymphoma tissues. 

  August 07, 2018

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• Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis. 

  August 01, 2018

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• Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2-/- mice by diminishing senescence of cholangiocytes. 

  July 05, 2018

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• Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism. 

  July 03, 2018

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• Differential effects of GLI2 and GLI3 in regulating cervical cancer malignancy in vitro and in vivo. 

  July 02, 2018

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• The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse. 

  July 02, 2018

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• Nuclear shape and orientation features from H&E images predict survival in early-stage estrogen receptor-positive breast cancers. 

  June 29, 2018

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• Osteopontin isoforms differentially promote arteriogenesis in response to ischemia via macrophage accumulation and survival. 

  June 29, 2018

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• miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation. 

  June 28, 2018

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• Phenotypic characterization of murine models of cerebral cavernous malformations. 

  June 26, 2018

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• ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. 

  June 08, 2018

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• Lack of plakoglobin impairs integrity and wound healing in corneal epithelium in mice. 

  May 25, 2018

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• Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling. 

  May 23, 2018

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