Laboratory Investigation

Articles Available on Medscape

• Distinctive Properties of Plaque-Type Dura Mater Graft-Associated Creutzfeldt-Jakob Disease in Cell-protein Misfolding Cyclic Amplification
  In this paper, the authors introduce a new method for identifying iatrogenic Creutzfeldt-Jakob disease using protein misfolding cyclic amplification.

  July 06, 2016

• Prolyl Isomerase Pin1 Promotes Survival in EGFR-Mutant Lung Adenocarcinoma Cells With an Epithelial-Mesenchymal Transition Phenotype
  The findings of this study suggest that inhibition of Pin1 activity could be a novel strategy for lung cancer treatment.

  May 13, 2016

• Loss of Antigenicity With Tissue Age in Breast Cancer
  Breast cancer specimens are often archived for many years for research or follow-up purposes. Do expression and detection of target biomarkers degrade over time in FFPE tissues?

  April 13, 2016

• WNT Signaling in Glioblastoma and Therapeutic Opportunities
  WNT signaling plays a crucial role in both CNS development and cancer. Could targeting WNT signaling be a viable therapeutic approach for glioblastoma?

  March 03, 2016

• Attenuation of Methylglyoxal-Induced Peritoneal Fibrosis: Immunomodulation by Interleukin-10
  Might immunomodulation with interleukin-10 offer an effective therapeutic strategy for prevention or treatment of peritoneal fibrosis, a complication of peritoneal dialysis?

  February 18, 2016

Table of Contents

2018 -

• Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis. 

  March 26, 2018

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• Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death. 

  March 26, 2018

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• Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial-mesenchymal transition. 

  March 26, 2018

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• A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome. 

  March 23, 2018

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• Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma. 

  March 15, 2018

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• Proteomic signature of circulating extracellular vesicles in dilated cardiomyopathy. 

  March 14, 2018

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• An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis. 

  March 14, 2018

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• Dectin-1 stimulates IL-33 expression in dendritic cells via upregulation of IRF4. 

  March 14, 2018

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• SOCS1-targeted therapy ameliorates renal and vascular oxidative stress in diabetes via STAT1 and PI3K inhibition. 

  March 14, 2018

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• miR-9-5p, miR-124-3p, and miR-132-3p regulate BCL2L11 in tuberous sclerosis complex angiomyolipoma. 

  March 14, 2018

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• Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis. 

  March 14, 2018

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• Patient-derived xenograft cryopreservation and reanimation outcomes are dependent on cryoprotectant type. 

  March 08, 2018

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• Correction to: Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections. 

  March 08, 2018

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• NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model. 

  March 06, 2018

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• Circulating tumor DNA measurement provides reliable mutation detection in mice with human lung cancer xenografts. 

  March 01, 2018

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• Lack of hepatic stimulator substance expression promotes hepatocellular carcinoma metastasis partly through ERK-activated epithelial-mesenchymal transition. 

  March 01, 2018

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• Pirfenidone reduces profibrotic responses in human dermal myofibroblasts, in vitro. 

  March 01, 2018

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• The extracellular domain of Her2 in serum as a biomarker of breast cancer. 

  February 28, 2018

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• The mitochondrial nucleoside diphosphate kinase (NDPK-D/NME4), a moonlighting protein for cell homeostasis. 

  February 28, 2018

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• TSG-6 secreted by bone marrow mesenchymal stem cells attenuates intervertebral disc degeneration by inhibiting the TLR2/NF-κB signaling pathway. 

  February 26, 2018

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• Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion. 

  February 22, 2018

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• Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients. 

  February 21, 2018

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• Adenylosuccinate lyase enhances aggressiveness of endometrial cancer by increasing killer cell lectin-like receptor C3 expression by fumarate. 

  February 21, 2018

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• Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma. 

  February 21, 2018

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• Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs. 

  February 21, 2018

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• Redox control of vascular smooth muscle cell function and plasticity. 

  February 20, 2018

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• Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma. 

  February 20, 2018

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• Cinnamaldehyde accelerates wound healing by promoting angiogenesis via up-regulation of PI3K and MAPK signaling pathways. 

  February 20, 2018

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• Endothelial smoothened-dependent hedgehog signaling is not required for sonic hedgehog induced angiogenesis or ischemic tissue repair. 

  February 16, 2018

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• A survey of metastasis suppressors in Metazoa. 

  February 16, 2018

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• A competitive cell-permeable peptide impairs Nme-1 (NDPK-A) and Prune-1 interaction: therapeutic applications in cancer. 

  February 15, 2018

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• Inducible nitric oxide synthase during the late phase of sepsis is associated with hypothermia and immune cell migration. 

  February 14, 2018

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• Modulation of small GTPase activity by NME proteins. 

  February 12, 2018

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• EPEC NleH1 is significantly more effective in reversing colitis and reducing mortality than NleH2 via differential effects on host signaling pathways. 

  February 02, 2018

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• ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients. 

  January 30, 2018

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• A humanized mouse model of liver fibrosis following expansion of transplanted hepatic stellate cells. 

  January 19, 2018

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• An in vitro system of autologous lymphocytes culture that allows the study of homeostatic proliferation mechanisms in human naive CD4 T-cells. 

  January 18, 2018

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• Inhibition of WNT/β-catenin signaling under serum starvation and hypoxia induces adipocytic transdifferentiation in human leiomyoma cells. 

  January 18, 2018

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• Disruption of CXCR3 function impedes the development of Sjögren's syndrome-like xerostomia in non-obese diabetic mice. 

  January 18, 2018

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• The role of metabolic enzymes in mesenchymal tumors and tumor syndromes: genetics, pathology, and molecular mechanisms. 

  January 16, 2018

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• Obtaining high quality transcriptome data from formalin-fixed, paraffin-embedded diagnostic prostate tumor specimens. 

  January 16, 2018

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• Use of multicolor fluorescence in situ hybridization to detect deletions in clinical tissue sections. 

  January 16, 2018

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• The 'known-knowns', and 'known-unknowns' of extracellular Nm23-H1/NDPK proteins. 

  January 16, 2018

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• Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy. 

  January 12, 2018

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• Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci. 

  January 12, 2018

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• SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis. 

  January 12, 2018

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• β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways. 

  January 12, 2018

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• Severe steatosis induces portal hypertension by systemic arterial hyporeactivity and hepatic vasoconstrictor hyperreactivity in rats. 

  January 11, 2018

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