The Journal of clinical investigation

(ISSN: 0021-9738, 1558-8238)

Table of Contents

From The Journal of clinical investigation

2023 -

  • Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. 
  • In situ expansion and reprogramming of Kupffer cells elicits potent tumoricidal immunity against liver metastasis. 
  • NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling. 
  • Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. 
  • Nutrient regulation of the islet epigenome controls adaptive insulin secretion. 
  • Therapeutic potential of convalescent plasma and SARS-CoV-2 hyperimmune immunoglobulins against BQ.1, BQ.1.1 and XBB variants. 
  • Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. 
  • Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks. 
  • Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans. 
  • Lysosomal lipid peroxidation regulates tumor immunity. 
  • Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. 
  • The gut signals to AGRP expressing cells of the pituitary to control glucose homeostasis. 
  • O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission. 
  • PP2Ac/STRN4 negatively regulates STING-Type I interferon signaling in tumor associated macrophages. 
  • BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils. 
  • Interleukin-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy. 
  • EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer. 
  • A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages. 
  • Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments. 
  • SLAMF7 regulates inflammatory response in macrophages during polymicrobial sepsis. 
  • The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain-of-function in cancer. 
  • Asparagine protects pericentral hepatocytes during acute liver injury. 
  • Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients. 
  • Targeting pleckstrin-2-Akt signaling reduces proliferation in myeloproliferative neoplasm models. 
  • YAP1 and WWTR1 expression inversely correlate with neuroendocrine markers in Merkel cell carcinoma. 
  • Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. 
  • A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain. 
  • Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis. 
  • Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. 
  • Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth. 
  • Pre-clinical and clinical evidence for suppression of alcohol intake by apremilast. 
  • Distinct early cellular kinetics in participants protected from colonization upon Bordetella pertussis challenge. 
  • Conversion of CD73hiFR4hi anergic T cells to IFN-γ-producing effector cells disrupts established immune tolerance. 
  • BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals. 
  • A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome. 
  • SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth onset type 2 diabetes. 
  • Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice. 
  • Clonally expanded HIV-1 proviruses with 5'-Leader defects can give rise to nonsuppressible residual viremia. 
  • Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. 

Journal Information