The Journal of clinical investigation

Table of Contents

2023 -

• Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis. 

  February 23, 2023

  • [ MEDLINE Abstract ]

• In situ expansion and reprogramming of Kupffer cells elicits potent tumoricidal immunity against liver metastasis. 

  February 23, 2023

  • [ MEDLINE Abstract ]

• NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling. 

  February 23, 2023

  • [ MEDLINE Abstract ]

• Glycolysis drives STING signaling to facilitate dendritic cell antitumor function. 

  February 23, 2023

  • [ MEDLINE Abstract ]

• Nutrient regulation of the islet epigenome controls adaptive insulin secretion. 

  February 23, 2023

  • [ MEDLINE Abstract ]

• Therapeutic potential of convalescent plasma and SARS-CoV-2 hyperimmune immunoglobulins against BQ.1, BQ.1.1 and XBB variants. 

  February 23, 2023

  • [ MEDLINE Abstract ]

• Local senolysis in aged mice only partially replicates the benefits of systemic senolysis. 

  February 21, 2023

  • [ MEDLINE Abstract ]

• Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks. 

  February 21, 2023

  • [ MEDLINE Abstract ]

• Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans. 

  February 16, 2023

  • [ MEDLINE Abstract ]

• Lysosomal lipid peroxidation regulates tumor immunity. 

  February 16, 2023

  • [ MEDLINE Abstract ]

• Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. 

  February 16, 2023

  • [ MEDLINE Abstract ]

• The gut signals to AGRP expressing cells of the pituitary to control glucose homeostasis. 

  February 14, 2023

  • [ MEDLINE Abstract ]

• O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• PP2Ac/STRN4 negatively regulates STING-Type I interferon signaling in tumor associated macrophages. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• BAM15 treats mouse sepsis and kidney injury, linking mortality, mitochondrial DNA, tubule damage, and neutrophils. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• Interleukin-1 receptor-associated kinase-3 acts as an immune checkpoint in myeloid cells to limit cancer immunotherapy. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancer. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• Host immunological responses facilitate development of SARS-CoV-2 mutations in patients receiving monoclonal antibody treatments. 

  February 09, 2023

  • [ MEDLINE Abstract ]

• SLAMF7 regulates inflammatory response in macrophages during polymicrobial sepsis. 

  February 07, 2023

  • [ MEDLINE Abstract ]

• The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain-of-function in cancer. 

  February 07, 2023

  • [ MEDLINE Abstract ]

• Asparagine protects pericentral hepatocytes during acute liver injury. 

  January 31, 2023

  • [ MEDLINE Abstract ]

• Single-cell characterization of anti-LAG3+anti-PD1 treatment in melanoma patients. 

  January 31, 2023

  • [ MEDLINE Abstract ]

• Targeting pleckstrin-2-Akt signaling reduces proliferation in myeloproliferative neoplasm models. 

  January 31, 2023

  • [ MEDLINE Abstract ]

• YAP1 and WWTR1 expression inversely correlate with neuroendocrine markers in Merkel cell carcinoma. 

  January 31, 2023

  • [ MEDLINE Abstract ]

• Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. 

  January 31, 2023

  • [ MEDLINE Abstract ]

• A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain. 

  January 26, 2023

  • [ MEDLINE Abstract ]

• Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis. 

  January 26, 2023

  • [ MEDLINE Abstract ]

• Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. 

  January 26, 2023

  • [ MEDLINE Abstract ]

• Monogenic disease analysis establishes that fetal insulin accounts for half of human fetal growth. 

  January 21, 2023

  • [ MEDLINE Abstract ]

• Pre-clinical and clinical evidence for suppression of alcohol intake by apremilast. 

  January 19, 2023

  • [ MEDLINE Abstract ]

• Distinct early cellular kinetics in participants protected from colonization upon Bordetella pertussis challenge. 

  January 17, 2023

  • [ MEDLINE Abstract ]

• Conversion of CD73hiFR4hi anergic T cells to IFN-γ-producing effector cells disrupts established immune tolerance. 

  January 17, 2023

  • [ MEDLINE Abstract ]

• BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammals. 

  January 17, 2023

  • [ MEDLINE Abstract ]

• A seed sequence variant in miR-145-5p causes multisystem smooth muscle dysfunction syndrome. 

  January 17, 2023

  • [ MEDLINE Abstract ]

• SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth onset type 2 diabetes. 

  January 13, 2023

  • [ MEDLINE Abstract ]

• Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice. 

  January 05, 2023

  • [ MEDLINE Abstract ]

• Clonally expanded HIV-1 proviruses with 5'-Leader defects can give rise to nonsuppressible residual viremia. 

  January 05, 2023

  • [ MEDLINE Abstract ]

• Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. 

  January 05, 2023

  • [ MEDLINE Abstract ]