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Hepatocellular Carcinoma: Looking for Sall4
This study supports the concept that the expression of Sall4 in hepatocellular carcinoma serves as a prognostic marker in liver cancers, and correlates well with cell and tumor growth.
July 08, 2013
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Antibiotics Improve Survival Rates Among Children With Severe Malnutrition
This study provides robust evidence that the inclusion of antibiotics in the treatment of uncomplicated severe malnutrition is effective.
July 01, 2013
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Treatment of Atrioventricular Block and Systolic Dysfunction With Biventricular Pacing
This review covers a trial comparing cardiac resynchronization therapy with RV pacing in patients with high-grade atrioventricular block.
June 17, 2013
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Continuous Versus Intermittent Androgen Deprivation Therapy
This brief review covers a study that sheds light on whether intermittent androgen deprivation therapy is as effective for metastatic prostate cancer as continuous androgen.
June 10, 2013
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Duloxetine Effective for Chemotherapy-Induced Painful Peripheral Neuropathy
This brief review covers the use of duloxetine in painful chemotherapy-induced neuropathy. How effective is it for reducing pain and improving quality of life?
June 03, 2013
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Mipomersen: An Antisense Oligonucleotide for Lowering LDL-Cholesterol in Patients With Homozygous Familial Hypercholesterolemia
This brief review covers the antisense oligonucleotide mipomersen, an orphan drug and a first-in-class drug for treatment of homozygous familial hypercholesterolemia.
May 28, 2013
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Nondemented, Very Elderly Subjects Have a High Prevalence of Positive Amyloid Scans
This study should be a wakeup call, urging caution interpreting PET scans in the oldest old and in patients who are cognitively asymptomatic.
May 20, 2013
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Revised Criteria for Screening Could Improve Sensitivity of Low-Dose CT Scanning for Lung Cancer Detection
This brief review describes new criteria that will help physicians determine which patients should be screened for lung cancer.
May 13, 2013
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Is CT Imaging Useful in the Evaluation of Vertigo in the Emergency Department?
This brief review sheds perspective on a study that evaluates the use of computed tomography in patients with vertigo.
May 06, 2013
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Recurrent Lyme Disease Is Due to Reinfection, Not Relapse
This brief review of a study on Lyme disease provides some answers to the long-standing controversy over whether the Lyme pathogen can cause relapsing, chronic disease, or both.
May 02, 2013
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Shedding Some (Sun)Light on Calcium and Vitamin D
This brief review offers some solid advice on the current issues of whether calcium and vitamin D supplements should be taken to prevent fractures.
April 19, 2013
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Patient Selection and Detection Thresholds in Lung Cancer Screening
Lung cancer screening with low-dose chest CT scans produces a 20% reduction in mortality from lung cancer, but what patients should be screened?
March 29, 2013
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Drug Shortages in the US: Causes and What the FDA Is Doing to Prevent New Shortages
The public health consequences of national drug shortages are sobering. This brief review describes why its happening and what is being done about it.
March 08, 2013
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Trial Fails to Demonstrate Advantage of Endovascular Treatment Following Intravenous tPA in Acute Stroke
Find out why this trial was halted.
March 01, 2013
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Effects of Body Size and Antihypertensive Treatments on Rates of Cardiovascular Events
This brief review discusses the obesity paradox in the context of study suggesting that the higher survival rates in obese hypertensive patients may be due to the drugs they are taking.
February 22, 2013
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Transfusions for Acute Upper Gastrointestinal Bleeding: The Seven-Gram Strategy
This brief review covers an important study that supports and justifies the 7-g/dL hemoglobin strategy for the management of acute upper gastrointestinal bleeding.
February 14, 2013
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Aspirin as a Cancer Prevention Agent
This brief review covers the latest evidence on aspirin as a preventive agent against cancer and offers some guidance.
February 08, 2013
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(Drug) Test that Baby Wash!
If your hospital is currently or plans to test infant urine samples for intrauterine drug exposure, think twice about what you use to clean up that newborn.
December 28, 2012
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Progress on Improving the Tolerability of Opioids
The finding of an opioid receptor variant, MOR1D, that does not alleviate pain, together with the discovery of an itch-specific receptor, GRPR, represents a noteworthy scientific breakthrough.
December 10, 2012
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Cardiovascular Risk Factors and the Risk of Peripheral Artery Disease in Men
This brief review covers an analysis that supports the importance of the conventional cardiovascular risk factors in the PAD population.
December 03, 2012
