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DPP-4 Inhibitors -- An Update on Alogliptin
Alogliptin was approved by the FDA in 2013, alone and in combination with other agents, for the management of type 2 diabetes. Why did it take so long?
March 28, 2014
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Treatment of Esophageal Varices With Carvedilol
Is carvedilol the beta blocker of choice for the prophylaxis of first variceal bleeding?
March 14, 2014
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Nonalcoholic Fatty Liver Disease: The Use of MRI for Quantifying Changes in Liver Fat
Liver biopsy is the gold standard for diagnosing NAFLD, but it is invasive and not practical for all patients. Could a noninvasive, MRI-based biomarker be the answer?
March 07, 2014
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Dimethyl Fumarate (TECFIDERA): A New Small Molecule Disease-Modifying Drug for Multiple Sclerosis
This brief update summarizes the pharmacological characteristics of dimethyl fumarate, a new disease-modifying drug which offers an alternative to fingolimod or teriflunomide in the treatment of multiple sclerosis.
February 28, 2014
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High-Dose Vitamin E Modestly Effective for Alzheimer's Disease
Could vitamin E supplementation help to slow the progression of Alzheimer's disease? This new article discusses the latest research.
February 21, 2014
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A Novel Brain-Computer Interface Approach to Deep Brain Stimulation for Parkinson's Disease
Can a brain-computer interface allow for individualization of deep brain stimulation?
November 25, 2013
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Effect of Metoprolol on Infarct Size When Used With Percutaneous Coronary Intervention
Current guidelines advocate only for initiation of beta blockade in patients presenting with an infarct. The METOCARD-CNIC trial examined IV metoprolol prior to reperfusion. Will it change practice?
November 11, 2013
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You Can't Go Home Again -- Risk Stratification and Acute Heart Failure
Patients with acute heart failure have an historically high rate of emergency department bounce back and hospital readmission. A new risk scoring system easily implemented in the ED may be the answer.
November 04, 2013
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The Zolpidem Paradigm Shift -- Why Now?
Zolpidem was first approved for insomnia 20 years ago. The FDA recently lowered the recommended starting dose for women and strengthened warnings about driving risk. The question is -- why now?
October 29, 2013
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Update on Mortality Risk Associated With the Off-label Use of Antipsychotic Medications for Dementia in the Elderly
Despite an FDA boxed warning, antipsychotics continue to be used to manage the troubling behaviors associated with dementia in the elderly. Read about the risks.
October 07, 2013
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Pazopanib and Sunitinib Compared
How do these 2 agents, with similar mechanisms of action and response rates, compare for the treatment of metastatic renal cancer?
September 30, 2013
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Brain-Machine Interface Might Aid Poststroke Rehabilitation
This brief review covers a brain-machine interface training program that improved motor scores in post-stroke patients even well after their initial injury.
September 23, 2013
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SGLT2 Inhibitors: FDA Approval of Canagliflozin for Type 2 Diabetes Therapy
Canagliflozin represents a significant departure in how glucosuria is approached, and has a novel, insulin-independent mechanism of action that reduces plasma glucose, body weight and blood pressure.
September 16, 2013
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Riociguat for Thromboembolic Pulmonary Hypertension
Riociguat is the first drug to demonstrate improved hemodynamics and function in patients with chronic thromboembolic pulmonary hypertension.
September 09, 2013
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Prognosis for Pericarditis With and Without Myocardial Involvement
This study suggests that pericarditis is associated with a good prognostic outcome, irrespective of the degree of myocardial involvement.
August 26, 2013
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Impact of Incomplete Angiographic Revascularization After PCI in ACS
Data from the ACUITY study help determine whether incomplete revascularization is associated with a higher risk for MACE.
August 19, 2013
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Pharyngitis?! Looks Like Strep -- Can I Treat or Must I Test?
This brief review provides best guidance on when to test and treat a patient with pharyngitis.
August 12, 2013
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Earlier Surgery in Medically Refractory Frontal Lobe Epilepsy Is Associated With Better Outcomes
This study confirms the benefit of surgery in focal epilepsy, and in medically refractory patients, the earlier the better.
July 29, 2013
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Short-Term versus Conventional Glucocorticoid Therapy in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
This study suggests that a shorter course of steroids may be sufficient for many patients with COPD exacerbations.
July 22, 2013
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Shorter Time to Treatment Associated With Better Outcomes in Ischemic Stroke
This remarkable study proves that the faster you can give tPA, the better the outcome.
July 15, 2013
