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Expert Review of Proteomics
(ISSN: 1478-9450, 1744-8387)
This journal no longer participates in Medscape Publishers' Circle Program. No new articles will be republished.
This review examines how proteomics can further our understand of platelet activation and platelet function in bleeding disorders, and identify potential new targets for antiplatelet therapy.
Using reverse-phase protein microarray, the authors were able to detect modified forms of HER2 in breast cancer tissue that, even in the absence of HER2 overexpression, could affect normal signaling.
This review describes a proximity ligation assay for in situ detection of protein complexes, which is able to detect and quantify many protein complexes simultaneously in the same tissue specimen.
This review compares the advantages and disadvantages of mass spectrometry and immunoassays in proteomics. To what extent does each provide the required combination of sensitivity and specificity?
In this review, the authors summarize the quantitative proteomic approaches being utilized for identification of miRNA targets, a key challenge in understanding the biological role of miRNAs.
Highlights of the European Proteomics Association 2012 Scientific Congress include the emerging field of cross-linking/mass spectrometry and a new a proteomics data repository.
The proteomic analysis of bone marrow plasma in chronic myeloid leukemia illustrates how powerful proteomics may be in the discovery of new therapeutics targeting resistance mechanisms.
Technological advances in proteomics have permitted a more effective search for novel biomarkers in stroke. What are the latest -- and most promising -- biomarker candidates?
Cancer stem cells may be the driving force behind tumor growth and recurrence, but little is known about their mechanisms. Proteomics is emerging as a powerful tool for increasing our understanding.
Prion diseases are uniformly fatal, and it's crucial to develop effective diagnostic assays for routine screening. Can proteomic technology be used to determine prion disease biomarkers?
The multifunctional signal protein angiopoietin-like protein 4, also known as the fasting-induced adipose factor, contributes to a multitude of physiological effects. What is its role in human health?
The authors review recent developments in 2D HPLC, which has emerged as a viable alternative to gel-based separation protocols in high-throughput bottom-up proteomics.
Using human saliva as an example, this review demonstrates how the results of proteomic studies can be influenced by methodology and the choice of instrument.
How can proteomic analyses be applied to gain insight into the pathogenesis of schizophrenia? This review summarizes current research, and highlights the search for novel biomarkers of schizophrenia.
The authors review new techniques for studying protein phosphorylation utilizing yeast as a model system, in an effort to better understand the roles of kinases in human disease.
Mission Statement:
Expert Review of Proteomics provides expert reviews, commentary and analysis on technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease.
