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Second-generation Antipsychotics in the Treatment of Major Depressive Disorder
This comprehensive review provides an overview of the current best evidence for the use of second-generation antipsychotics in treatment of patients with major depressive disorder.
September 10, 2013
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Gene Therapy for Parkinson's Disease
Despite intensive research, no currently available therapy for Parkinson's disease has shown continuing long-term efficacy. Where do we stand with gene therapy as a disease-modifying approach?
July 26, 2013
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Antihypertensives, Angiotensin, Glucose and Alzheimer's Disease
Recent evidence suggests that some antihypertensive medications may improve cognition independent of their blood pressure lowering effects. Might they be effective in treating Alzheimer's disease?
June 27, 2013
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MRI in Headache
Most patients don't need imaging for common headache, but the decision to image or not is not always clear-cut. What are the 'red flags' which indicate a need for a brain MRI?
May 27, 2013
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Individual Treatment Response in Attention-Deficit/Hyperactivity Disorder
Key to addressing the treatment needs of patients with ADHD is the development of psychometrically validated instruments to measure treatment response.
April 22, 2013
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New Approaches to Bedside Monitoring in Stroke
The latest advances in bedside stroke monitoring -- including noninvasive techniques of ICP monitoring, near-infrared spectroscopy, and transcranial Doppler -- are improving outcomes for stroke patients.
March 14, 2013
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Use of Intravenous Recombinant Tissue Plasminogen Activator in Patients Outside the Defined Criteria
A considerable number stroke patients successfully treated with rtPA would have been excluded if guidelines were strictly followed. What are the risks and benefits of this off-label use?
February 27, 2013
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Neuropsychopharmacology of Auditory Hallucinations
This intriguing article demonstrates how pharmacological fMRI can help elucidate the effects of antipsychotic drugs on brain activation during episodes of auditory hallucinations.
February 13, 2013
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Drug Treatments for the Neuropsychiatric Complications of Parkinson's Disease
Neuropsychiatric sequelae of Parkinson's disease can be diverse, ranging from mood disturbances to cognitive impairment and even psychosis. How should one approach pharmacological management?
January 30, 2013
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Rationale for Combining Glutamatergic and Cholinergic Approaches in the Symptomatic Treatment of Alzheimer's Disease
Disease-modifying drugs for AD remain elusive, but two classes of symptom-ameliorating drugs -- cholinergic and glutamatergic therapies -- are currently available. Is a combined approach the way forward?
January 16, 2013
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Psychotherapy in Adult Attention Deficit Hyperactivity Disorder
This article presents a concise overview of the latest research on various psychotherapeutic interventions for the treatment of adult ADHD.
November 20, 2012
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Behavioral Interventions in Multiple Sclerosis
This interesting review suggests that behavioral interventions may not only be able to ameliorate symptoms of MS, but may in fact have disease modifying potential.
October 16, 2012
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Could Transcranial Direct Current Stimulation Have Unexpected Additional Benefits in the Treatment of Depressed Patients?
The benefits of tDCS in depressed patients may extend beyond simply mood regulation, potentially facilitating cognitive enhancement and pain relief.
August 27, 2012
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Ironing Out Neurodegeneration
Can regular consumption of iron-rich foods in childhood provide cognitive benefits later in life? New studies are investigating the genetic links between iron, the brain, and the HFE gene.
June 13, 2012
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Saved By the Bell: Does Working Too Much Increase the Likelihood of Depression?
Evidence regarding the association between long working hours and mental health is accumulating. Could chronic psychological stress caused by overwork contribute to the development of depression?
May 23, 2012
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A Novel Treatment for Glioblastoma: Integrin Inhibition
The prognosis for the majority of patients with glioblastoma remains discouraging. This review focuses on the potential of anti-integrin strategies as a promising therapeutic option.
April 06, 2012
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Clinical Applications of Imaging Disease Burden in Multiple Sclerosis
MRI has become an indispensable tool for diagnosing and monitoring the course of multiple sclerosis, but other techniques, such as PET imaging and MR spectroscopy, may also play pivotal roles.
March 13, 2012
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Current Acute Stroke Trials and Their Potential Impact on the Therapeutic Time Window
An overview of existing and novel thrombolytic approaches which are under investigation for treatment of acute ischemic stroke, with an eye towards expanding the crucial therapeutic time window.
February 09, 2012
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The Use of Newer Antiepileptic Drugs in Patients With Renal Failure
Seizures and chronic kidney disease often coexist, but treatment can be challenging, especially for those on dialysis. This practical guide reviews the use of antiepileptic drugs in these patients.
December 29, 2011
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Problems and Controversies in Status Epilepticus
Status epilepticus is a relatively common neurologic emergency that requires immediate aggressive treatment, but for obvious reasons, clinical trials are few. What's the best management?
December 06, 2011
