BMC Clinical Pathology

Articles Available on Medscape

• Primary Leiomyosarcoma of the Submandibular Gland: A Case Report
  Leiomyosarcoma is a rare malignant mesenchymal tumor; and even rarer in the salivary gland. How was diagnosis ascertained in this case?

  January 29, 2016

• Membranous CD24 Expression As Detected by the Monoclonal Antibody SWA11 Is a Prognostic Marker in Non-Small Cell Lung Cancer Patients
  This study analyzed immunohistochemical staining characteristics and the prognostic value of expression of the cell surface protein CD24 in non-small cell lung cancer.

  January 14, 2016

• Comparing Gene Expression Data From Formalin-Fixed, Paraffin Embedded Tissues and qPCR With That From Snap-Frozen Tissue and Microarrays for Modeling Outcomes of Patients With Ovarian Carcinoma
  The authors evaluated the use of several tissue preservation methods for comparing measurements of gene expression used to model clinical outcomes in ovarian cancer.

  December 14, 2015

• Enrichment of the Embryonic Stem Cell Reprogramming Factors Oct4, Nanog, Myc, and Sox2 in Benign and Malignant Vascular Tumors
  This study suggests that the protein expression of embryonic stem cell reprogramming factors is enriched in benign as well as malignant vascular tumors.

  November 30, 2015

• Impact of Add-On Laboratory Testing at an Academic Medical Center: A Five Year Retrospective Study
  How do add-on orders impact the workload of the clinical laboratory? This study analyzed add-on ordering patterns over an extended time period.

  November 16, 2015

• Comparison of Time-Motion Analysis of Conventional Stool Culture and the BD MAX(tm) Enteric Bacterial Panel (EBP)
  A new molecular platform may reduce turnaround time, associated laboratory processes, and costs compared to conventional stool culture methods for diagnosis of bacterial diarrhea.

  August 27, 2015

• Prognostic and Predictive Significance of Podocalyxin-Like Protein Expression in Pancreatic and Periampullary Adenocarcinoma
  This study examined the clinicopathological prognostic and predictive significance of PODXL expression in pancreatic and periampullary adenocarcinoma

  August 20, 2015

• Extracellular Vesicles: Potential Applications in Cancer Diagnosis, Prognosis, and Epidemiology
  What role might extracellular vesicles play in cancer? Might they be useful as biomarkers or therapeutic targets?

  August 13, 2015

• Length of Prostate Biopsies Is Not Necessarily Compromised by Pooling Multiple Cores in One Paraffin Block: An Observational Study
  Does pooling prostate biopsy specimens in the same biopsy container and resulting paraffin block negatively impact the quality of the biopsy?

  August 06, 2015

• A Reliable Method for the Detection of BRCA1 and BRCA2 Mutations in Fixed Tumour Tissue Utilising Multiplex PCR-Based Targeted Next Generation Sequencing
  The authors present a new method of detecting BRCA variants in DNA extracted from formalin-fixed paraffin-embedded ovarian and breast tumor specimens, using next-generation sequencing.

  July 30, 2015

• Primary Gastric Actinomycosis
  In this report, a rare case of primary gastric actinomycosis diagnosed in a gastroscopic biopsy is discussed.

  April 24, 2015

• A Putative Role for Homocysteine in the Pathophysiology of Acute Bacterial Meningitis in Children
  Might a build-up of homocysteine within the CNS play a role in the pathophysiology of brain damage associated with acute bacterial meningitis?

  February 18, 2015

• Estrogen Receptor Alpha and Androgen Receptor Are Commonly Expressed in Well-Differentiated Liposarcoma
  Might hormonal receptor expression be a factor in liposarcoma, as it is in other cancers such as breast and prostate cancer?

  January 05, 2015

• Ultrastructural Characterization of Primary Cilia in Pathologically Characterized Human Glioblastoma Multiforme (GBM) Tumors
  This study demonstrates that defects in cilia expression and function are a hallmark of glioblastoma multiforme tumors and correlate with their unrestrained growth.

  December 05, 2014

• Characterisation and Prognostic Value of Tertiary Lymphoid Structures in Oral Squamous Cell Carcinoma
  Is the presence of tertiary lymphoid structures associated with clinical outcome in oral squamous cell carcinoma?

  November 21, 2014

• A Simple and Cost-Effective Method of DNA Extraction From Small Formalin-Fixed Paraffin-Embedded Tissue for Molecular Oncologic Testing
  The authors describe a novel DNA extraction method to obtain high quality genomic DNA from minute quantities of formalin-fixed, paraffin-embedded tissue.

  October 09, 2014

• Expression of KOC, S100P, Mesothelin and MUC1 in Pancreatico-Biliary Adenocarcinomas
  This study investigated the utility of four candidate biomarkers for the immunohistochemical characterization of pancreatico-biliary adenocarcinomas.

  September 25, 2014

• Serum TFF3 May Be a Pharamcodynamic Marker of Responses to Chemotherapy in Gastrointestinal Cancers
  This study investigated the feasibility of protein serum trefoil factor 3 as a biomarker for gastrointestinal cancer, as well as a pharmacodynamic predictor of response to chemotherapy.

  September 05, 2014

• alphaB-crystallin Is a Marker of Aggressive Breast Cancer Behavior but Does Not Independently Predict for Patient Outcome
  Is the heat-shock protein alphaB-crystallin a useful biomarker in breast cancer prognosis?

  August 22, 2014

• Thymidine Phosphorylase Expression Is Associated With Time to Progression in Patients With Metastatic Colorectal Cancer
  This study examined the relationship of thymidine phosphorylase expression in patients with advanced colorectal cancer to tumor response during 5-FU-based chemotherapy.

  August 20, 2014