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Enzymatic Functional Assays of Coagulation Using Small Sample Volumes
Is thrombophilia panel testing using a small plasma volume and a digital microfluidic platform as accurate as current methods which require large blood volumes and long turn-around times?
March 12, 2018
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Pharmacogenetics-Based Warfarin Dosing in Patients With Cardiac Valve Replacement
This study identifies genetic polymorphisms which might be helpful for adjusting warfarin dosage to an effective and safe level in patients with cardiac valve replacement.
February 12, 2018
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Clinical and Antibiotic Management of Urinary Tract Infections Pre- and Postimplementation of the CLINITEK AUWi System From Siemens to Screen Out Negative Urine Samples Submitted for Culture
Might screening for suspected UTIs using the CLINITEK AUWi System reduce unnecessary administration of antibiotics?
January 11, 2018
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Opioid Use Disorders, Medication-Assisted Treatment, and the Role of the Laboratory
This review focuses on considerations surrounding urine drug testing, examining the role of both presumptive and definitive testing methods.
December 28, 2017
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Impact of Fasting on Complete Blood Count Assayed in Capillary Blood Samples
Recommendations for fasting before a complete blood count are inconsistent. Does food consumption impact CBC results?
December 26, 2017
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The Clinical Utility of Measuring IgG Subclass Immunoglobulins During Immunological Investigation for Suspected Primary Antibody Deficiencies
In what clinical situations is IgG subclass measurement a useful tool?
December 20, 2017
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Coagulation Testing in the Core Laboratory
This article presents a primer on the mechanisms involved in hemostasis and coagulation pathways, highlighting various methods of coagulation testing and special coagulation studies.
December 18, 2017
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Underestimation of Low Density Lipoprotein-Cholesterol With the Friedewald Equation Versus a Direct Homogenous Low Density Lipoprotein-Cholesterol Assay
Given that the Friedewald equation has been shown to underestimate LDL-C concentrations, what method should be used to accurately ascertain LDL-C levels?
December 13, 2017
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SurePath Specimens Versus ThinPrep Specimen Types on the COBAS 4800 Platform
This study compared two different methodologies of cytologic preparation of cervical specimens for HPV screening. Which method more accurately identified HPV infection?
December 11, 2017
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Variable Potassium Concentrations: Which Is Right and Which Is Wrong?
This case highlights the difficulty in distinguishing between hyperkalemia in a setting of possible tumor lysis syndrome and reverse pseudohyperkalemia. How should the correct etiology be determined?
December 06, 2017
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Establishment of Reference Interval for Alkaline Phosphatase in Healthy Children of Various Ethnicities, Aged 0-12 Years
This study sought to establish a reference interval for alkaline phosphatase in healthy children, aiming to provide a basis for screening, diagnosing, and monitoring bone or liver-related diseases.
December 04, 2017
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The American Society for Clinical Pathology's 2015 Wage Survey of Medical Laboratories in the United States
How do your wages stack up to others in your field? Are salaries generally up for laboratory professionals? Read the results of this comprehensive biennial survey in this report.
November 29, 2017
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Plasma Transfusion Demystified: A Review of the Key Factors Influencing the Response to Plasma Transfusion
This review aims to assist physicians in navigating common pitfalls associated with plasma transfusion, which is often used inappropriately.
November 27, 2017
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The Challenges of Daratumumab in Transfusion Medicine
Daratumumab, used to treat multiple myeloma, attaches to the red blood cell reagents used in blood banks, complicating the antibody identification work-up. How can this issue be overcome?
June 05, 2017
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A Simple PCR-RFLP Method for Genotyping of IFNL4 rs368234815 Polymorphism in Patients With Chronic Hepatitis C
The authors present a rapid, inexpensive, and easy to perform method for genotyping of the IFNL4 rs368234815 polymorphism in hepatitis C.
May 15, 2017
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Ficin-Treated Red Cells Help Identify Clinically Significant Alloantibodies Masked as Reactions of Undetermined Specificity in Gel Microtubes
The authors present a transfusion protocol for using ficin treatment to determine the specificity of antibodies that would otherwise be classified as antibodies of undetermined significance
April 24, 2017
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What Clinical Laboratorians Should Do in Response to Extremely Low Hemoglobin A1c Results
What are the possible causes and clinical implications associated with very low HbA1c results?
April 03, 2017
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Haemophilus Species as a Urinary Tract Pathogen
How often do Haemophilus spp. occur as urinary tract pathogens, and under what circumstances should they be suspected?
March 13, 2017
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Folate Insufficiency Due to Celiac Disease in a 49-Year-Old Woman of Southeast Asian-Indian Ethnicity
This case demonstrates that a micronutrient deficiency, in this case folate, may be the first clinical indication of celiac disease.
February 01, 2017
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Clostridium sordellii as an Uncommon Cause of Fatal Toxic Shock Syndrome in a Postpartum 33-Year-Old Asian Woman, and the Need for Antepartum Screening for This Clostridia Species in the General Female Population
Should screening for Clostridium sordelli be implemented for all women following childbirth? The fatal outcome of this case suggests it might be wise.
January 16, 2017
