Neurobiology of disease

(ISSN: 0969-9961, 1095-953X)

Table of Contents

From Neurobiology of disease

2019 - 132

  • One-carbon metabolism supplementation improves outcome after stroke in aged male MTHFR-deficient mice. 
  • Pioglitazone improves working memory performance when administered in chronic TBI. 
  • Sex-dependent impaired locomotion and motor coordination in the HdhQ200/200 mouse model of Huntington's Disease. 
  • The impact of silencing feed-forward parvalbumin-expressing inhibitory interneurons in the cortico-thalamocortical network on seizure generation and behaviour. 
  • Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson's disease. 
  • Human NPCs can degrade α-syn fibrils and transfer them preferentially in a cell contact-dependent manner possibly through TNT-like structures. 
  • Friedreich ataxia- pathogenesis and implications for therapies. 
  • Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease. 
  • Purkinje cell-specific Grip1/2 knockout mice show increased repetitive self-grooming and enhanced mGluR5 signaling in cerebellum. 
  • Corrigendum to "Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS" Neurobiology of Disease 124 (2019) 340-352. 
  • TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration. 
  • KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway. 
  • Multigenerational epigenetic inheritance: One step forward, two generations back. 
  • Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice. 
  • Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. 
  • Obesity-related cognitive impairment: The role of endothelial dysfunction. 
  • Immunotherapy in Parkinson's disease: Current status and future directions. 
  • HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome. 
  • Smooth muscle cell-specific knockout of FBW7 exacerbates intracranial atherosclerotic stenosis. 
  • Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo. 
  • Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation. 
  • Dystonia and levodopa-induced dyskinesias in Parkinson's disease: Is there a connection? 
  • RANTES-induced invasion of Th17 cells into substantia nigra potentiates dopaminergic cell loss in MPTP mouse model of Parkinson's disease. 
  • Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment. 
  • Factors in the disease severity of ATP1A3 mutations: Impairment, misfolding, and allele competition. 
  • Leptin deficiency reverses high metabolic state and weight loss without affecting central pathology in the R6/2 mouse model of Huntington's disease. 
  • Antibody-based therapies for Huntington's disease: current status and future directions. 
  • Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine. 
  • Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease. 
  • Neurotrophin receptor p75 mediates amyloid β-induced tau pathology. 
  • Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs. 
  • "Depressed" caudate and ventral striatum dopamine transporter availability in de novo Depressed Parkinson's disease. 
  • Stem cell factor and granulocyte colony-stimulating factor promote brain repair and improve cognitive function through VEGF-A in a mouse model of CADASIL. 
  • Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation. 
  • The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease. 
  • Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. 
  • Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy. 
  • Metabolic interventions in Autism Spectrum Disorder. 
  • The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease. 
  • Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology. 
  • TAF1-gene editing alters the morphology and function of the cerebellum and cerebral cortex. 
  • Cranial burr hole with erythropoietin administration induces reverse arteriogenesis from the enriched extracranium. 
  • Molecular genetics of congenital myotonic dystrophy. 
  • Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3. 
  • Perturbed Ca2+-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia. 
  • Progressive neuroanatomical changes caused by Grin1 loss-of-function mutation. 
  • TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes. 
  • Dystonia and Parkinson's disease: What is the relationship? 

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