Medscape Conference Coverage, based on selected sessions at:

TCT 2008: Transcatheter Cardiovascular Therapeutics 20th Annual Scientific Symposium

October 12 - 17, 2008; Washington, DC

This activity is not sanctioned by, nor a part of, the Cardiovascular Research Foundation. Conference news does not receive grant support and is produced independently.

Conference News

  • US Physicians Eager for Corevalve Trial After European Results

    New data from 18 European countries on the fully percutaneous aortic valve speak to low 30-day mortality and improved valve function sustained over the longer term. So why the hold-up in the US, where nary a feasibility study has been conducted?
    Heartwire, October 27, 2008
  • Provisional Stenting Wins in Bifurcations: BBC ONE

    Provisional T-stenting using the Taxus stent, instead of the crush or culotte techniques, is associated with a lower rate of death, MI, and target vessel failure at one year, results from the BBC ONE trial show.
    Heartwire, October 23, 2008

    The COOL-RCN investigators used a catheter that essentially acts as an "intravenous refrigerator," cooling the body from the inside out, but it failed to decrease the risk of acute kidney damage caused by iodinated contrast agents.
    Heartwire, October 22, 2008
  • CMS Denies More Coverage for Carotid Stenting

    Critics say the CMS should have waited for pending publications of the SAPPHIRE, CAPTURE 2, and EXACT data before announcing its decision, especially as new results from PROTECT, EMPIRE, and EPIC indicate that stroke, death, and MI rates are continuing to decline.
    Heartwire, October 22, 2008

    An embolic-protection and aspiration device delivered proximally to the lesion in primary PCI results in better immediate microvascular flow in STEMI patients compared with primary PCI alone. Although the immediate benefits did not hold up over time, investigators believe the early reperfusion will translate into better outcomes.
    Heartwire, October 20, 2008
  • Nuts And Bolts of DAPT

    Device companies contacted by heartwire about their role in the Dual Antiplatelet Therapy Trial say nothing has yet been finalized about trial funding or "in-kind" sponsorship. Hammering out these details may yet jeopardize the $100M DES trial.
    Heartwire, October 17, 2008
  • European Data Raise Safety Questions About Endeavor Stent

    In a comparison with the Cypher stent, SORT-OUT III showed an increased risk of MI and stent thrombosis with the Endeavor zotarolimus-eluting stent at nine months, while two-year registry data suggest an increase risk in all-cause mortality. While everybody urged caution in interpreting the findings, experts say the results are a warning signal.
    Heartwire, October 16, 2008

    In addition to reducing TLR rates at 12 months, the Taxus stent was equivalent to its bare-metal counterpart in terms of major cardiovascular adverse events, including death, MI, stroke, and stent thrombosis, report investigators.
    Heartwire, October 16, 2008
  • 20,000-Patient DAPT Trial Announced

    Eight companies have agreed to sponsor the study, selecting the Harvard Clinical Research Institute to command the 33-month, $100-million dollar study. The announcement effectively shelves CODA, the dual antiplatelet study first proposed by Duke but rejected by the necessary industry funders.
    Heartwire, October 16, 2008
  • Fractional Flow Reserve in FAME

    Investigators report that fractional flow reserve-guided PCI reduced the risk of death, MI, or repeat revascularization by 30% and death or MI by 35%, when compared with the current practice of using angiography to guide stenting decisions.
    Heartwire, October 15, 2008
  • SYNTAX Subset Data

    The analyses can be viewed only as "hypothesis generating," since SYNTAX was negative. But the data suggest that in low- or intermediate-risk patients with left main disease, DES and CABG are both "reasonable" options, but in three-vessel disease, only the lowest-risk patients should be considered as candidates for DES instead of surgery.
    Heartwire, October 15, 2008
  • Cypher, Taxus Equal in Left Main Disease: ISAR-Left Main

    Both types of drug-eluting stents performed similarly in left main subjects, leading to two-year outcomes comparable to those from CABG registries.
    Heartwire, October 15, 2008
  • Transfemoral Data From PARTNER EU and SCORE

    High survival following transcatheter valve placement via the transfemoral approach reflects increased operator skill and lower-risk patients than the transapical arms of the study, experts say.
    Heartwire, October 14, 2008
  • Catania Stent in ATLANTA

    Investigators reported no cases of stent thrombosis at 12 months in patients implanted with the stent, as well as no adverse clinical events, despite stopping dual antiplatelet therapy at 30 days.
    Heartwire, October 13, 2008
  • Carotid Stenting Registry

    Investigators caution that the data are preliminary, but the 30-day risk of stroke and death observed in clinical trials is lower when more experienced operators perform the procedure.
    Heartwire, October 13, 2008
  • MI Risks/Benefits Neutral

    Leaders of some of the more provocative DES studies in recent years seem to agree that other factors may be contributing to the apparent survival benefit with DES seen in recent registries but that it is at least safe to conclude that risk of death or MI is not increased with their use. But many also argue for a bigger role for bare-metal stents.
    Heartwire, October 13, 2008

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