As we navigate the ever-evolving landscape of diabetic foot disease management, I'd like to discuss the updated 2023 International Working Group on the Diabetic Foot (IWGDF) guidelines and their implications for our practice. The goal is to create a common language of risk that is easily related from clinician to clinician to patient.
Whatever language we use, though, the problem we face is vast:
Diabetic foot ulcers affect approximately 18.6 million people worldwide and 1.6 million in the United States each year.
They are associated with high rates of premature death, with a 5-year mortality rate of 30%. This rate is > 70% for those with above-foot amputations, worse than all but the most aggressive cancers.
The direct costs of treating diabetic foot ulcers in the United States is estimated at $9-13 billion annually.
Over 550 million people worldwide have diabetes, with 18.6 million developing foot ulcers annually. Up to 34% of those with diabetes will develop a foot ulcer.
About 20% of those with a diabetic foot ulcer will undergo amputation, a major cause of which is infection, which affects 50% of foot ulcers.
Up to 20% of those with a foot ulcer require hospitalization, with 15%-20% undergoing amputation. Inequities exist in diabetes-related foot complications:
Rates of major amputation are higher in non-Hispanic Black, Hispanic, and Native American populations compared with non-Hispanic White populations.
Non-Hispanic Black and Hispanic populations present with more advanced ulcers and peripheral artery disease, and are more likely to undergo amputation without revascularization attempt.
The IWGDF, a multidisciplinary team of international experts, has recently updated its guidelines. This team, comprising endocrinologists, internal medicine physicians, physiatrists, podiatrists, and vascular surgeons from across the globe, has worked tirelessly to provide us with a comprehensive guide to managing diabetes-related foot ulcers.
The updated guidelines address five critical clinical questions, each with up to 13 important outcomes. The systematic review that underpins these guidelines identified 149 eligible studies, assessing 28 different systems. This exhaustive research has led to the development of seven key recommendations that address the clinical questions and consider the existence of different clinical settings.
One of the significant updates in the 2023 guidelines is the recommendation of SINBAD — site, ischemia, neuropathy, bacterial infection, area, and depth — as the priority wound classification system for people with diabetes and a foot ulcer. This system is particularly useful for interprofessional communication, describing each composite variable, and conducting clinical audits using the full score. However, the guidelines also recommend the use of other, more specific assessment systems for infection and peripheral artery disease from the Infectious Diseases Society of America (IDSA)/IWGDF when resources and an appropriate level of expertise exist.
The introduction of the Wound, Ischemia and foot Infection (WIfI) classification system in the guidelines is also a noteworthy development. This system is crucial in assessing perfusion and the likely benefit of revascularization in a person with diabetes and a foot ulcer. By assessing the level of wound ischemia and infection, we can make informed decisions about the need for vascular intervention, which can significantly affect the patient's outcome. This can be done simply by classifying each of the three categories of wound, ischemia, or foot infection as none, mild, moderate, or severe. By simplifying the very dynamic comorbidities of tissue loss, ischemia, and infection into a useable and predictive scale, it helps us to communicate risk across disciplines. This has been found to be highly predictive of healing, amputation, and mortality.
We use WIfI every day across our system. An example might include a patient we recently treated:
A 76-year-old woman presented with a wound to her left foot. Her past medical history revealed type 2 diabetes, peripheral neuropathy, and documented peripheral artery disease with prior bilateral femoral-popliteal bypass conducted at an external facility. In addition to gangrenous changes to her fourth toe, she displayed erythema and lymphangitic streaking up her dorsal foot. While she was afebrile, her white cell count was 13,000/µL. Radiographic examinations did not show signs of osteomyelitis. Noninvasive vascular evaluations revealed an Ankle-Brachial Index of 0.4 and a toe pressure of 10 mm Hg. An aortogram with a lower-extremity runoff arteriogram confirmed the obstruction of her left femoral-popliteal bypass.
Taking these results into account, her WIfI score was determined as: wound 2 (moderate), ischemia 3 (severe), foot infection 2 (moderate, no sepsis), translating to a clinical stage 4. This denotes a high risk for major amputation.
Following a team discussion, she was taken to the operating room for an initial debridement of her infection which consisted of a partial fourth ray resection to the level of the mid-metatarsal. Following control of the infection, she received a vascular assessment which ultimately constituted a femoral to distal anterior tibial bypass. Following both of these, she was discharged on a negative-pressure wound therapy device, receiving a split-thickness skin graft 4 weeks later.
The guidelines also emphasize the need for specific training, skills, and experience to ensure the accuracy of the recommended systems for characterizing foot ulcers. The person applying these systems should be appropriately trained and, according to their national or regional standards, should have the knowledge, expertise, and skills necessary to manage people with a diabetes-related foot ulcer.
As we continue to navigate the complexities of diabetes-related foot disease, these guidelines serve as a valuable compass, guiding our decisions and actions. They remind us of the importance of continuous learning, collaboration, and the application of evidence-based practice in our work.
I encourage you to delve into these guidelines. Let's use them to improve our practice, enhance our communication, and, ultimately, provide better care for our patients.
Follow Dr Armstrong on Twitter @DGArmstrong
Lead image: Jorge Salcedo | Dreamstime.com
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Cite this: A Step Forward in Diabetic Foot Disease Management - Medscape - Aug 08, 2023.