Case Report and Literature Review of Giant Cutaneous Malignant Melanoma

What's Keeping Patients Away?

Jamie A Mawhinney, BA, BMBCh, MRCS (Eng); Adrien Yvon, MBChB, MRes (Dist), MRCS (Eng); Shahid Masood, MBBS, FFCPS (Plast), FRCS (Plast)

Disclosures

ePlasty. 2022;22(e45) 

In This Article

Abstract and Introduction

Abstract

Background: Giant cutaneous malignant melanoma (MM) is a term that has previously been used to define lesions that are at least 10 cm in diameter or 48 mm in thickness. Such tumours are rare. There is no substantial body of evidence considering why patients may delay presentation with MM until they reach this size. This case report presents one of the largest cases of giant cutaneous MM to date and the first in the literature to show excellent response to adjuvant immunotherapy. The patient was treated successfully and remains alive and well 12 months following initial surgery. A review of the literature discussing giant MM identified a significant need for education on the importance of seeking medical attention in order to prevent advanced disease, especially for vulnerable individuals.

Introduction

Giant cutaneous malignant melanoma (MM) is a rare manifestation of melanoma and a term that has previously been used to define lesions that are at least 10 cm in diameter[1] or 48 mm in thickness.[2] Due to the large size of these lesions, there is a necessary delay in presentation by patients, although there is no substantial body of evidence considering why this might be the case. Furthermore, because of the rarity of these lesions, there is a lack of strong evidence as to whether they may require any specific management in comparison to thinner metastatic melanomas. This case report presents a unique case of giant cutaneous MM, reviews the existing medical literature around this rare condition, and discusses potential factors influencing late presentation.

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