First Lady Tests Positive for Coronavirus Again in 'Rebound' Case

Jay Croft

August 26, 2022

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

Just like her husband, President Joe Biden, did earlier this summer, the first lady has tested positive for COVID-19 in a "rebound" case after being treated with the antiviral therapy Paxlovid.

Jill Biden tested positive by antigen testing again on Wednesday, after testing negative on Tuesday, said her spokeswoman, Kelsey Donohue, in a statement.

The Washington Post reported that the first lady has not had new symptoms and is isolating in Delaware.

Jill Biden, 71, first tested positive for the coronavirus on August 16. She began a course of Paxlovid. She has been double-vaccinated and boosted twice, and experienced mild symptoms, her office said at the time.

The president, 79, tested negative Wednesday morning on an antigen test, The Post reported. "The White House said he would be tested more regularly and would mask for 10 days when indoors and in proximity to others, in accordance with guidance from the Centers for Disease Control and Prevention."

President Biden first tested positive on July 21, received Paxlovid, and had a rebound.

"Physicians have warned that people who receive the antiviral medication Paxlovid can experience rebound infections days after initially testing negative, although data on the frequency of the occurrence and its long-term effects remain unclear," the newspaper reported.

Early reports indicated between 1% and 2% of people treated with Paxlovid experienced symptoms again. Another study in June put the figure at 6%. Doctors are determining if patients should receive treatment for a longer period to prevent recurrence.


The Washington Post: "First lady Jill Biden tests positive in rebound case of coronavirus."


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.