A risk score based on routinely collected variables at the start of admission to ICU and invasive ventilation can predict mortality of ventilated ARDS patients, with a moderate performance. And further evaluation of our model is required.
ARDS: Acute respiratory distress syndrome;; ICU: Intensive care unit; IMV: Invasive mechanical ventilation; MIMIC: Medical information mart for intensive care; eICU-CRD: eICU Collaborative research database; INR: International normalized ratio; RDW: Blood cell distribution width; AaDO2: Alveolo-arterial oxygen difference; BUN: Blood urea nitrogen; WBC: White blood cell; SAPS II: Simplified acute physiology score II; APACHE II/III/IV: Acute physiology and chronic health evaluation II/III/IV; OASIS: Oxford acute severity of illness score; SOFA: Sequential organ failure assessment; APPS: Age; PaO2/FiO2: Plateau pressure score.
This study was supported by the National Natural Science Foundation of China (Nos. 81870069, 81970071, 81770077 and 82070084), the Major special projects of the Ministry of science and technology (No. 2020YFC0841300) and The Science and Technology Program of Guangzhou, China (202102010366). The funding sources were not involved in study design; collection, analysis, and interpretation of data; or writing of the manuscript.
Availability of data and materials
The datasets are available in the website of PhysioNet. MIMIC-III: https://physionet.org/content/mimiciii/1.4/; MIMIC-IV: https://physionet.org/content/mimiciv/1.0/; eICU: https://physionet.org/content/eicu-crd/2.0/ The above mentioned links are the direct persistent links to the datasets and researchers need to completed the course Protecting Human Research Participants on the website of National Institutes of Health and obtained the certification prior to accession.
Ethics approval and consent to participate
The MIMIC-III, MIMIC-IV and eICU databases have received ethical approval from the Institutional Review Boards at Beth Israel Deaconess Medical Center and Massachusetts Institute of Technology. As the databases do not contain protected health information, a waiver of informed consent was included in the approval from the Institutional Review Boards at Beth Israel Deaconess Medical Center and Massachusetts Institute of Technology. Therefore, this manuscript does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee. All methods in this study were carried out in accordance with relevant guidelines and regulations (declarations of Helsinki).
Consent for publication
BMC Pulm Med. 2022;22(268) © 2022 BioMed Central, Ltd.