The HRG levels on POD 1 in patients who developed postoperative complications were significantly lower than those in patients who did not develop postoperative complications. Furthermore, the ability of HRG to predict postoperative complications was superior to that of WBC and CRP and similar to that of PCT and P-SEP. Thus, HRG levels may be useful biomarkers for predicting postoperative complications. Future studies are needed on the usefulness of HRG in predicting postoperative complications based on clinical departments and complications.
We would like to thank Mariko Shimizu (Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) for her help in obtaining informed consent and collecting samples and Hiroko Yasuda (Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan) for her help in obtaining informed consent and gathering samples and measurements. We would also like to thank Editage (www. edita ge. com) for English language editing.
This work was supported by KAKENHI provided by the Japan Society for the Promotion of Science [grant number, 19K18297] to KK.
Availability of data and materials
The datasets generated and analyzed during the present study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
This study was performed in accordance with the Declaration of Helsinki and Ethical Guidelines for Medical and Health Research Involving Human Subjects. This study was approved by the institutional ethics review board of Okayama University Hospital (Okayama, Japan) on August 14, 2020 (approval number: 2007–006). According to the instruction of the ethics review board, after describing the study protocol, verbal informed consent for study participation was obtained from all patients. This information has been preserved as an electronic medical record. All patients received a detailed description of the study and were provided with contact information in case of further clarification, any additional questions, or concerns.
Consent for publication
Prior to inclusion in the study, verbal informed consent for publication was obtained from all patients. This information has been preserved as an electronic medical record.
BMC Anesthesiol. 2022;22(232) © 2022 BioMed Central, Ltd.