Histidine-rich Glycoprotein as a Novel Predictive Biomarker of Postoperative Complications in Intensive Care Unit Patients

A Prospective Observational Study

Masahiko Oiwa; Kosuke Kuroda; Naoya Kawanoue; Hiroshi Morimatsu


BMC Anesthesiol. 2022;22(232) 

In This Article


The HRG levels on POD 1 in patients who developed postoperative complications were significantly lower than those in patients who did not develop postoperative complications. Furthermore, the ability of HRG to predict postoperative complications was superior to that of WBC and CRP and similar to that of PCT and P-SEP. Thus, HRG levels may be useful biomarkers for predicting postoperative complications. Future studies are needed on the usefulness of HRG in predicting postoperative complications based on clinical departments and complications.