A Randomized Trial of Ketorolac and Metoclopramide for Migraine in the Emergency Department

Lawrence P. Richer MD, MSc; Samina Ali MD; David W. Johnson MD; Rhonda J. Rosychuk PhD; Amanda S. Newton PhD; Brian H. Rowe MD, MSc


Headache. 2022;62(6):681-689. 

In This Article


In pediatric patients presenting to the ED for acute treatment migraine headache, the addition of ketorolac to standard care with metoclopramide failed to result in improved outcomes. Our findings do not support routinely combining ketorolac with metoclopramide, as it failed to provide additional pain relief. Well-designed clinical trials comparing current commonly used acute therapies for pediatric migraine are needed to fill the void in high quality evidence for this common condition. Future studies may also focus on prevention of headache recurrence as well as the time to resolution of pain in the ED.