Biomarkers to Guide the use of Antibiotics for Acute Exacerbations of COPD (AECOPD)

A Systematic Review and Meta-Analysis

George Hoult; David Gillespie; Tom M. A. Wilkinson; Mike Thomas; Nick A. Francis


BMC Pulm Med. 2022;22(194) 

In This Article


In conclusion, there are several biomarkers that show promise for use in differentiating bacterial from non-bacterial AECOPD, with serum CRP having the most convincing evidence. However, given the low number of studies identified and large amount of heterogeneity between studies, it is not possible to draw firm conclusions about the value of using biomarkers to identify bacterial exacerbations of COPD. Further well-powered high-quality studies are needed, especially on markers with some evidence of value such as serum CRP and PCT, and sputum IL-8, TNF-α, IL-1β, IL-6, MPO and NE.