Cutaneous Manifestations of SARS-CoV-2 Infection

Thy Huynh; Xavier Sanchez-Flores; Judy Yau; Jennifer T. Huang


Am J Clin Dermatol. 2022;23(3):277-286. 

In This Article


Many skin manifestations due to SARS-CoV-2 infection have been reported. The most common cutaneous patterns associated with COVID-19 include CBLL, maculopapular lesions, urticarial lesions, vesicular lesions, and livedoid lesions. EM-like lesions, MIS-C, and MIS-A are also reported but rare. Our review is limited by publication bias and dermatologists should consider the possibility of additional undescribed cutaneous findings. The timing and morphology of these reactions are diverse and thus it is difficult to identify a 'fil rouge' for cutaneous patterns associated with COVID-19. However, with the exception of MIS-C and MIS-A, cutaneous reactions occur in the setting of active infection. Thus, other infectious and non-infectious etiologies should be considered if there is no evidence of COVID-19 infection. Dermatologists play an important role in the response to the SARS-CoV-2 pandemic by aiding in early recognition of skin lesions. Awareness and identification of these cutaneous manifestations can help with early diagnosis, management, and treatment of SARS-CoV-2.