Effect of Intensive Blood Pressure Control on Subtypes of Mild Cognitive Impairment and Risk of Progression From SPRINT Study

Sarah A. Gaussoin MS; Nicholas M. Pajewski PhD; Gordon Chelune PhD; Maryjo L. Cleveland MD; Michael G. Crowe PhD; Lenore J. Launer PhD; Alan J. Lerner MD; Jennifer Martindale-Adams EdD; Linda O. Nichols PhD; Paula K. Ogrocki PhD; Bonnie C. Sachs PhD; Kaycee M. Sink MD; Mark A. Supiano MD; Virginia G. Wadley PhD; Valerie M. Wilson MD; Clinton B. Wright MD; Jeff D. Williamson MD; David M. Reboussin PhD; Stephen R. Rapp PhD


J Am Geriatr Soc. 2022;70(5):1384-1393. 

In This Article


Hypertension is one of the most modifiable risk factors for cognitive impairment. Blood pressure control is relatively low cost, readily available, and easy to administer, making it an attractive choice for preventing cognitive decline in the population. Intensive blood pressure treatment reduced the risk for amnestic and multi-domain subtypes of MCI, a transitional state between normal cognitive functioning and dementia. An adjudication of MCI was associated with increased risk of progression to dementia and death among individuals at cardiovascular risk, highlighting the relevance of MCI as a clinical outcome. Intensive blood pressure control represents a viable option in preventing or delaying a major public health threat in the United States and beyond.