Probiotic in the Prevention of Ventilator-Associated Pneumonia in Critically Ill Patients

Evidence From Meta-Analysis and Trial Sequential Analysis of Randomized Clinical Trials

Yue-chen Sun; Chen-yi Wang; Hai-li Wang; Yao Yuan; Jian-hong Lu; Lei Zhong


BMC Pulm Med. 2022;22(168) 

In This Article


In conclusion, our cumulative meta-analysis strengthens the evidence that prophylactic use of probiotics may be a possible effective non-antibiotic option in reducing the incidence of VAP in critically ill ventilated patients. However, the long-run effects of probiotics safety on individuals warrant further studies, especially in special groups of critically ill patients (i.e. neonates/children, immunocompromised, severely debilitated patients, etc.).