In conclusion, patients with gout frequently flare during the whole first year, especially during months 3–6, but flares are much less frequent during year 2 when treated with ULT. Baseline crystal depositions predict flares over 2 years, supporting ULT early during disease course.
BMI: Body mass index; BMQ: Beliefs about Medicines Questionnaire; CI: Confidence interval; CRP: C-reactive protein; DECT: Dual-energy computed tomography; ESR: Erythrocyte sedimentation rate; HAQ: Health Assessment Questionnaire; HRQoL: Health-related quality of life; NOR-Gout: Gout in Norway; NSAID: Non-steroidal anti-inflammatory drugs; OMERACT : Outcome measures in rheumatoid arthritis clinical trials; OR: Odds ratio; SCQ: Self-Administered Comorbidity Questionnaire; SD: Standard deviation; ULT: Uratelowering therapy.
We thank research secretary Mona Thorkildsen for organization and research nurses Gina Stenberg, Anita Reinhard, Heidi Lunoe, and Ingerid Muller who contributed as trained study nurses in the follow-up of the treat-to-target approach. We also thank patient representatives Espen Reksten og Ole Petter Synestvedt.
The study was funded by Diakonhjemmet Hospital and was performed by employees at National Advisory Unit on Rehabilitation in Rheumatology (NKRR) and Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.
Availability of data and materials
The datasets used during the current study are available from the corresponding author on reasonable request.
Ethics approval and consent to participate
The study was approved by the Norwegian Regional Committee for Medical and Health Research Ethics South East (reference number 2015/990), and the patients gave their written informed consent according to the Declaration of Helsinki.
Consent for publication
Arthritis Res Ther. 2022;24(88) © 2022 BioMed Central, Ltd.
Copyright to this article is held by the author(s), licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original citation.