Abstract and Introduction
Over the past few decades, several therapeutical advances have improved the outcomes of patients with a reduced left ventricular ejection fraction (LVEF) and evidence of heart failure (HF) in the early post-myocardial infarction (MI) period. Landmark trials have established beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEis) or angiotensin receptor-blocking agents (ARBs), and mineralocorticoid receptor antagonists (MRAs) as the 'backbone' neurohormonal modulating therapy for patients who had an MI complicated by left ventricular systolic dysfunction (LVSD) and HF.[2–5] Beyond these neurohormonal antagonists, lipid-lowering drugs, new anti-platelet and anti-thrombotic agents, and advanced reperfusion and revascularization techniques have contributed to an important reduction of recurrent cardiovascular events and mortality in this population.
Eur Heart J. 2022;43(14):1428-1431. © 2022 Oxford University Press
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