Comparison of Propofol-nalbuphine and Propofol-fentanyl Sedation for Patients Undergoing Endoscopic Retrograde Cholangiopancreatography

A Double-blind, Randomized Controlled Trial

Peiqi Wang; Yan Chen; Ying Guo; Jiangbei Cao; Hong Wang; Weidong Mi; Longhe Xu


BMC Anesthesiol. 2022;22(47) 

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In conclusion, we demonstrated that sedation with propofol-nalbuphine had advantages over propofol-fentanyl for the ERCP procedure because the former produced less respiratory depression and surgical interruption. Furthermore, nalbuphine can produce adequate analgesia and help to maintain stable haemodynamics in patients undergoing ERCP. Therefore, acombination of propofol and nalbuphineis more efficient and safer for patients during procedural sedation in ERCP.