The Endocannabinoid System and Related Lipids as Potential Targets for the Treatment of Migraine-related Pain

Rosaria Greco PhD; Chiara Demartini PhD; Anna Maria Zanaboni BSc; Miriam Francavilla MSc; Roberto De Icco MD, PhD; Lara Ahmad MD; Cristina Tassorelli MD, PhD


Headache. 2022;62(3):227-240. 

In This Article


This narrative review is based on literature retrieved from the PubMed/MEDLINE database. The database was searched for basic and clinical studies dealing with cannabis effects or endocannabinoid system (ECS) modulation in migraine by combining the keywords "migraine" or "headache" or "pain" with "endocannabinoid system" or "cannabinoids" or "cannabis" or "cannabidiol" or "cannabinoid (CB) receptors" or "FAAH inhibitor," "MAGL inhibitor," "NAAA inhibitor," or "dual blockers."