SGLT2 Inhibitors: The Statins of the 21st Century

Eugene Braunwald


Eur Heart J. 2022;43(11):1029-1030. 

In This Article

Abstract and Introduction


A relatively small number of drugs have been responsible for major advances in medical practice. The discovery, development, and elucidation of the mechanisms of action of aspirin, penicillin, and statins are remarkable success stories, each with some surprises and each crowned by a Nobel Prize. The sodium glucose co-transporter inhibitors have been proven effective in the treatment of type 2 diabetes mellitus, various forms of heart failure, and kidney failure and represent the, or one of the, major pharmacological advances in cardiovascular medicine in the 21st century.