Cytokine Signatures Differentiate Systemic Sclerosis Patients at High Versus Low Risk for Pulmonary Arterial Hypertension

Kathleen D. Kolstad; Avani Khatri; Michele Donato; Sarah E. Chang; Shufeng Li; Virginia D. Steen; Paul J. Utz; Purvesh Khatri; Lorinda Chung


Arthritis Res Ther. 2022;24(39) 

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This study illustrated distinct cytokine profiles that can distinguish SSc patients who are at high-risk for or have PAH from SSc patients who are at low risk for PAH and HC. We anticipate these data could be used to risk stratify SSc patients and guide therapy. These data may provide potential mechanistic targets to increase our understanding of SSc-PAH and support therapeutic innovation in the future.