Early Clinical Performance of an Adaptive Self-Assembling Barrier Scaffold in Nonhealing Chronic Wounds

A Review of Six Cases

Daniel Kapp, MD, PA; Laura Pfendler, PT, DPT, CWS; Lou D'Oro, MD; Randall Wolcott, MD

Disclosures

Wounds. 2022;34(1):20-30. 

In This Article

Materials and Methods

The adaptive self-assembling barrier scaffold is supplied as a lyophilized peptide in a complete kit with the sterile contents for reconstitution and application. The preparation instructions are as follows: (1) inspect kit contents, remove vial caps, and swab tops with the alcohol wipe; (2) with a syringe and 18 g hypodermic needle, transfer 1.5 mL of water into the aSABS peptide vial and shake to dissolve; (3) draw solution into a syringe and replace the needle with an 18 g blunt applicator; and (4) apply the solution to the wound in a back-and-forth motion.

For each case reported, aSABS was prepared and applied as described in the instructions for use. Secondary dressings were applied to cover the wound and were changed per standard practice in each clinic. The adaptive self-assembling barrier scaffold was applied in the clinic weekly, with the exception of 1 case in which it was applied every 2 weeks. Institutional Review Board (IRB) reviews and approval were not required because use of aSABS was in accordance with the US Food and Drug Administration-cleared indications for use. Patient consent was obtained by the respective clinicians for use of the images and observations provided.

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