Olive Oil Intake Tied to Reduced Mortality

Marlene Busko 

January 10, 2022

In an observational study of more than 90,000 US healthcare professionals, consuming even a small amount of olive oil was associated with reduced total mortality.

Compared to men and women who rarely or never consumed olive oil (the lowest intake), those who consumed greater than 0.5 tablespoon/day or more than 7 g/day (the highest intake) had a 19% lower mortality risk over a 28-year follow-up, starting from an average age of 56 years.

Moreover, compared to those with the lowest olive oil intake, those with the highest intake had a 19% lower cardiovascular disease (CVD) mortality, a 17% lower risk of dying from cancer, a 29% lower risk of dying from neurodegenerative disease, and an 18% lower risk of dying from respiratory disease during follow-up.

The researchers estimate that replacing 10 g/day of margarine, butter, mayonnaise, or dairy fat with the same amount of olive oil is associated with an 8% to 34% lower risk of death from various causes.

The study by Marta Guasch-Ferré, PhD, and colleagues was published online January 10 in the Journal of the American College of Cardiology.

Results Support Plant-Based Dietary Fat Recommendations

"Our results support current dietary recommendations to increase the intake of olive oil and other unsaturated vegetable oils in place of other fats to improve overall health and longevity," the researchers summarize.

However, "I wouldn't say that olive oil is the only way to help you live longer," Guasch-Ferré, a senior research scientist in the Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, cautioned in an interview with theheart.org | Medscape Cardiology.

"Other things are very important, such as not smoking, doing physical activity, etc, but one recommendation could be to try to eat more plant-based food including olive oil and healthy fat," she added, and to use it for cooking, salad dressing, and baking, and substitute it for saturated fat or animal fat, especially for cooking.

The study suggests that people should "consume a more plant-based diet and prioritize fatty acids such as olive oil because they have a better nutritional composition (high in phenols and antioxidants), instead of using butter or margarines or other animal fats that have been shown to have detrimental effects for health," she added, which is consistent with recommendations in the Dietary Guidelines for Americans.

"That said," Guasch-Ferré summarized, "replication is needed in other cohorts and populations to see if the results are similar."

In an accompanying editorial, Susanna C. Larsson, PhD, writes that "this was a well-designed study, with long-term follow-up and repeated measurements of dietary intake and other risk factors for diseases."

"However, the difference in olive oil consumption between those with the highest and those with the lowest/no olive oil consumption was very low (0.5 tablespoon) and a [12%] reduced mortality risk was observed already at a much lower intake (0.5 teaspoon, about 1.5 g/day) of olive oil," she noted in an email to theheart.org | Medscape Cardiology.

"It's a bit hard to believe that such a small amount could have an independent effect on mortality risk," Larsson, associate professor of epidemiology at the Karolinska Institutet, Stockholm, Sweden, cautioned.

Like Guasch-Ferré, she noted that "just adding one or two teaspoons of olive oil to the diet each day will likely not change the risk of mortality."

Rather, "people may need to make larger changes in the whole diet, not focus on fat only. An overall healthier diet, rich in non-refined plant-based foods (vegetables, whole grains, nuts), low/no intake of processed foods, and a switch to healthier fat (eg, olive oil) is needed."

Importantly, "this study cannot say anything about causality, that is, whether it's olive oil specifically that reduces mortality risk or if there are many other beneficial factors that act together to reduce mortality rate among those with high olive oil consumption."

The researchers acknowledge this observational study limitation and that the findings may not be generalizable to other populations.

Novel Findings Regarding Alzheimer's  and Respiratory Disease

Larsson highlights two novel findings of this study.

First, it showed a 27% reduction in risk of dementia-related mortality for those in the highest versus lowest category of olive oil consumption. "Considering the lack of preventive strategies for Alzheimer's disease and the high morbidity and mortality related to this disease, this finding, if confirmed, is of great public health importance," she said.

Second, the study reported an inverse association of olive oil consumption with risk of respiratory disease mortality. "Because residual confounding from smoking cannot be ruled out," Larsson said, "this finding is tentative and requires confirmation in a study that is less susceptible to confounding, such as a randomized trial."

And although the current study and previous studies have found that consumption of olive oil may have health benefits, she identified several remaining questions.

"Are the associations causal or spurious?" she noted. Is olive oil consumption protective for certain cardiovascular diseases like stroke or atrial fibrillation only, as has been shown in other studies, or also for other major diseases and causes of death, she added. What is the amount of olive oil required for a protective effect?

Further, is the potential effect related to monounsaturated fatty acids (MUFAs) or phenolic compounds; that is, "is the protective effect confined to polyphenol-rich extra virgin olive oil or are refined olive oil and other vegetable oils as beneficial? More research is needed to address these questions," she concludes.

"Further studies are needed," the researchers agree, "to confirm the association of olive oil consumption with reduced mortality, clarify the mechanisms responsible, and quantify the dose/volume boundaries around this effect."  

Virgin Olive Oil Has More Polyphenols

Olive oil, a key component of the Mediterranean diet, is high in MUFAs, especially oleic acid, as well as vitamin E and polyphenols, which contribute to its anti-inflammatory and antioxidant properties, the researchers explain.

Virgin olive oil, produced by mechanically pressing ripe olives, contains multiple bioactive and antioxidant components and has an acidity of < 1.5%. And extra-virgin olive oil is produced the same way but has a higher quality, more intense taste, and lower acidity (< 1%).

Refined or processed olive oil contains less phytochemicals, as some are lost during processing; it usually contains more than 80% refined oil, plus virgin oil added back to enhance flavor, and may also be labeled "pure" or "light." However, refined olive oil "still has a good amount of healthy fatty acids but less bioactive compounds," Guasch-Ferré noted.

Until now, no large prospective study has examined the link between olive oil intake and all-cause and cause-specific mortality in a US population, where olive oil consumption is limited compared with Mediterranean countries.

The researchers identified 60,582 women in the Nurses' Health Study and 31,801 men in the Health Professionals Follow-up Study who were free of CVD or cancer in 1990, the first year that food frequency questionnaires in these studies asked about olive oil.

Participants replied to questionnaires every 4 years that asked about use of olive oil (for salad dressing, baking, frying, sautéing, and spreading on bread), other vegetable oils (eg, corn, safflower, soybean, canola oil), margarine, butter, and dairy fat. The researchers averaged the consumption of these fats during the follow-up years.

From 1990 to 2019, the average consumption of olive oil increased from 1.6 g/day to 4 g/day. Margarine in the 1990s contained saturated fat and trans fats, whereas more recently margarine contains beneficial olive oil or vegetable fat, Guasch-Ferré noted.

Baseline olive oil consumption in this US population "differed remarkably" from that in the Spanish population in the PREDIMED (Prevención con Dieta Mediterránea) trial, which was, on average, 20 to 22 g/day of extra virgin olive oil and 16 to 18 g/day of refined/mixed olive oil, Larsson pointed out.

Because olive oil consumption was so low in this US study, the researchers did not distinguish between virgin/extra-virgin olive oil and refined/processed olive oil.

The participants were almost all White (99%) and were generally healthier than in the average US population; on average, they had a body mass index of 25.3 to 25.8 kg/m2 and ate 4.8 to 7.2 fruits and vegetables/day.

Those with the highest olive oil consumption were more physically active, had a healthier diet, were more likely to have Southern European or Mediterranean ancestry, and were less likely to smoke.

During 28 years of follow-up, 36,856 participants died. The researchers classified the deaths into five categories: CVD, cancer, neurodegenerative disease (including Alzheimer's disease, Parkinson's disease, multiple sclerosis), respiratory disease (such as chronic obstructive pulmonary disease), and all other causes (including suicide, injury, infections, diabetes, and kidney disease).

After adjusting for multiple confounders, compared with participants who rarely or never consumed olive oil, those in the highest quartile for olive oil consumption had a decreased risk of death from all-causes (hazard ratio [HR], 0.81; 95% CI, 0.78 - 0.84) and from CVD (HR, 0.81; 95% CI, 0.75 - 0.87), cancer (HR, 0.83; 95% CI, 0.78 - 0.89), neurodegenerative disease (HR, 0.71; 95% CI, 0.64 - 0.78), and respiratory disease (HR, 0.82; 95% CI, 0.72 - 0.93). 

There was no decrease in mortality in models where the researchers substituted olive oil for vegetable oil, suggesting that vegetable oils may provide similar health benefits as olive oil.

The research was supported by grants from the National Institutes of Health. Guasch-Ferré was supported by the American Diabetes Association. Co-author Salas-Salvadó is partially supported by the Catalan Institution for Research and Advanced Studies and received the virgin olive oil that was used in the PREDIMED and PREDIMED-Plus studies from the Patrimonio Communal Olivalero and Hojiblanca (Málaga, Spain). The other study authors and Larsson have reported no relevant financial relationships.

J Am Coll Cardiol. Published online January 10, 2022. Abstract, Editorial

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