Acute and Chronic Neurological Disorders in COVID-19

Potential Mechanisms of Disease

Erin F. Balcom; Avindra Nath; Christopher Power


Brain. 2022;144(12):3576-3588. 

In This Article

Future Perspectives

Given the mounting impact of SARS-CoV-2 infection globally together with the increasing recognition of associated neurological disorders, it is imperative to define the types of COVID-19 related neurological syndrome, including those caused directly by viral infection versus those arising from systemic illness, the impact of different viral variants on neurological disease, as well as identifying informative diagnostic tools and effective therapies. GWAS studies have identified susceptibility genes for severe respiratory illness with COVID.[174,175] Similar studies to identify host factors associated with neurological complications would also be useful. The long-term neurological sequelae of COVID-19 remain unclear and await delineation in longitudinal studies. The neurodevelopmental impacts of COVID-19 are also unknown in utero as well as in infants or adolescents; this issue could have substantial lasting effects that require further investigation. Finally, a more comprehensive understanding of the pathogenic mechanisms underpinning the neurological syndromes associated with COVID-19 will advance therapeutic options for affected patients.