Treatment of chronic leg ulcers of venous or mixed (venous or arterial) origin with HA cream is safe, well tolerated, and results in a higher rate of healing than a neutral comparator cream. From the results, HA is a major structural component of the extracellular matrix and based on the results of the study appears to have a major role in wound healing.
The authors thank Ray Hill, an independent medical writer, who provided technical writing support funded by IBSA Institut Biochimique S.A. (Lugano, Switzerland). The authors thank Simone Cazzaniga, a member of Centro Studi GISED, who measured target ulcer areas using a validated image analysis system in blind conditions. The authors thank all the CROMSOURCE (Verona, Italy) staff involved in coordinating and managing the clinical trial. The authors thank all the clinical research sites that participated in the study.
Wounds. 2021;33(11):285-295. © 2021 HMP Communications, LLC