Efficacy and Safety of a Hyaluronic Acid–Containing Cream in the Treatment of Chronic, Venous, or Mixed-Origin Leg Ulcers

A Prospective, Multicenter Randomized Controlled Trial

Jacek Mikosinski, MD, PhD; Anna Di Landro, MD; Karolina Kasztalska-Kazmierczak, PhD; Emilie Soriano, MSc, PharmD; Carol Caverzasio, MSc; Daniela Binelli, MStat; Bruno Falissard, MD, PhD; Olivier Dereure, MD, PhD


Wounds. 2021;33(11):285-295. 

In This Article


Treatment of chronic leg ulcers of venous or mixed (venous or arterial) origin with HA cream is safe, well tolerated, and results in a higher rate of healing than a neutral comparator cream. From the results, HA is a major structural component of the extracellular matrix and based on the results of the study appears to have a major role in wound healing.