Systematic Review & Meta-Analysis of Positron Emission Tomography/Computed Tomography and Bone Scan in the Diagnosis of Prostate Lesions

Jiafu Wang; Yue Han; Lin Lin; Linhan Zhang; Jin Li; Huiqi Gao; Peng Fu


Transl Androl Urol. 2021;10(11):4231-4240. 

In This Article


In this study, 3 articles related to the diagnosis of bone metastases by 68Ga-PSMA PET/CT and BS were screened to compare the diagnostic value of the two methods. The results of the meta-analysis showed that 68Ga-PSMA PET/CT had clear advantages over BS in the diagnosis of bone metastases of malignant prostate tumors, and could improve diagnostic accuracy. The shortcomings of this study lie in the small sample size and the lack of unified diagnostic criteria for each study; these criteria are easily influenced by subjective factors associated with individual researchers and may result in implementation bias. Unified diagnostic criteria are therefore required for further exploration. For cases with fewer bone metastases, it is often difficult to make an accurate judgment from a BS, while 68Ga-PSMA PET/CT can show soft tissues and organs in addition to bones to find metastatic lesions. 68Ga-PSMA PET/CT not only generates clear images, but can also accurately distinguish the pleura, ribs, and muscles of the chest wall. In conclusion, this study supports the use of PET/CT scans for the clinical diagnosis of bone metastases from malignant prostate lesions.