Evaluation of the Effect of Clinical Characteristics and Intensive Care Treatment Methods on the Mortality of Covid-19 Patients Aged 80 Years and Older

Sibel Oba; Mustafa Altınay; Aysel Salkaya; Hacer Şebnem Türk

Disclosures

BMC Anesthesiol. 2021;21(291) 

In This Article

Results

A total of 174 patients 80 years and older were included in the study. Demographic and clinical characteristics of patients were presented comparatively as survivor and non-survivor groups in Table 1. Twenty-four patients (13.8%) were older than 90 years old. Mean age of the non-survivor group was 86 and was statistically significantly high compared with the survivor group (p = 0.037).

The mean CRP (p = 0.011), PCT (p = 0.030), Ferritin (p = 0.002) and LDH (p = 0.019) values were statistically significantly high in the non-survivor group. The mortality rate of the patients who had IMV was also statistically significantly high (p < 0.001) compared to patients who had HFNC and/or NIMV. Albumin (p = 0.032) value and the rate of treatment with HFNC and/or NIMV (p = 0.002) were statistically significantly low in non-survivor group compared to the survivor group. The cut-off value of the prognosis power of the inflammatory parameters was determined with ROC analysis (Figure 1, Table 2). Cut-off values determining mortality, sensitivity, specificity, NPV, PPV, accuracy rates of inflammatory parameters (CRP, PCT, Ferritin, WBC) was presented at Table 3.

Figure 1.

Inflammatory parameters in ROC curve

The evaluation of the risk factors for mortality which was conducted with univariate logistic regression analysis in a model with variables p < 0,250 showed that age, CRP (≥96.5), PCT (≥0.31) Ferritin (≥338), IMV were the most significant prognostic parameters for mortality (p = 0.011 p = 0.001 p = 0.002 p = 0.004) (Table 4).

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