People Living with HIV Are at Risk of Multiple Comorbidities

Pavankumar Kamat


November 19, 2021


  • People living with HIV (PLHIV) in the UK had an increased risk of developing multiple comorbid conditions.

Why this matters

  • The findings emphasise the importance of regular reviews for PLHIV to monitor the development of comorbidities in line with the British HIV Association quality guidelines.

Study design

  • The study included 2945 PLHIV and 5890 matched HIV-negative control participants, identified using data from the UK Clinical Practice Research Datalink and linked Hospital Episode Statistics (1988-2017).

  • The risk of developing comorbidities, including central nervous system disorders, end-stage renal disease, osteoporosis, type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), hypertension, stroke and cancer, was evaluated.

  • Funding: Gilead Sciences Ltd.

Key results

  • PLHIV vs control group had an increased risk of developing (adjusted HR [aHR]; 95% CI):

    • incident sleep disorders (1.76; 1.42-2.20; P<.0001);

    • depression (1.66; 1.41-1.97; P<.0001);

    • osteoporosis (3.92; 2.38-6.44; P<.0001);

    • stroke (2.14; 1.39-3.30; P=.0006);

    • cancer (1.94; 1.59-2.39; P<.0001); and

    • renal disease (1.25; 1.02-1.53; P=.0340).

  • Risks of anxiety (1.21; 0.97-1.51; P=.0826), hypertension (1.05; 0.87-1.26; P=.63), T2DM (1.09; 0.84-1.43; P=.51), and CVD (1.13; 0.88-1.45; P=.34) were not significantly higher in the PLHIV vs control group.


  • Study did not account for HIV duration or antiretroviral therapy duration.

Jones BI, Freedman A, Thomas MJ, Villalba-Mendez C, Sathia L, Flanagan D, Francis S, Currie CJ. Comorbid diseases and conditions in people with HIV in the UK. Curr Med Res Opin. 2021 Nov 11 [Epub ahead of print]:1-15. doi: 10.1080/03007995.2021.2003671. PMID: 34761727

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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