Review Article

Vaccination for Patients With Inflammatory Bowel Disease During the COVID-19 Pandemic

Jayne Doherty; Sean Fennessy; Roisin Stack; Neil O' Morain; Garret Cullen; Elizabeth J. Ryan; Cillian De Gascun; Glen A. Doherty


Aliment Pharmacol Ther. 2021;54(9):1110-1123. 

In This Article


Study Selection

A comprehensive literature search was conducted for relevant literature (published articles and abstracts) by performing a systematic search of two databases: PubMed and Cochrane Library CENTRAL. No restrictions were applied to language or publication date. Keywords used were "inflammatory bowel disease" or "crohn's disease" or "ulcerative colitis" and/or "vaccine response" or "Influenza" or "Hepatitis B" or "Varicella" or "COVID-19 vaccination" or "vaccine uptake." Current European and American guidelines on current vaccinations in patients with IBD and guidelines on vaccination against COVID-19 infection were also reviewed. Eligible articles were reviewed and the quality was assessed by two independent reviewers.

Inclusion/Exclusion Criteria

Studies pertaining to or referencing the following topics were eligible for inclusion: (a) vaccine uptake in patients with IBD; (b) differences in the innate and adaptive immunity in patients with IBD; (c) vaccine response rates in patients with IBD; (d) COVID-19 vaccines; (e) response rates to COVID-19 vaccines in the IBD community. Case series or case reports were excluded due to high risk of publication bias. Studies that reported insufficient data on the outcomes of interest were also excluded.