MWA can be associated with a wide array of neuroimaging findings. In the acute presentation of new neurologic symptoms, several imaging findings can potentially distinguish MA from stroke or seizure, although clinical judgment remains paramount. In an asymptomatic patient with MWA, WMAs should be expected but not necessarily at a higher prevalence compared with MWoA. Additional research to improve our understanding of the relevance of imaging changes in MWA will further our knowledge of aura and migraine pathophysiology. Similarly, a variety of imaging modalities with research applications continue to advance our understanding of MWA.
ADC, apparent diffusion coefficient; BOLD, blood oxygenation level-dependent; CADASIL, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; CAMERA, Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis; CSD, cortical spreading depression; CT, computed tomography; FHM1, familial hemiplegic migraine type 1; FHM2, familial hemiplegic migraine type 2; fMRI, functional MRI; GMV, gray matter volume; HM, hemiplegic migraine; MWA, migraine with aura; MWoA, migraine without aura; MRA, magnetic resonance angiogram; MRI, magnetic resonance imaging; SWI, susceptibility-weighted imaging; WMA, white matter abnormality; WMH, white matter hyperintensity.
Thank you to Diana Almader-Douglas, MSL, for her contributions to the medical literature search.
Headache. 2021;61(9):1324-1333. © 2021 Blackwell Publishing