Narrative Review of Neuroimaging in Migraine With Aura

Karissa N. Arca MD; Juliana H. VanderPluym MD; Rashmi B. Halker Singh MD


Headache. 2021;61(9):1324-1333. 

In This Article


With the assistance of a Health Sciences librarian, we performed a review of the literature addressing MWA and neuroimaging in PubMed with an initial date restriction of 5 years and filtered for English language. The following MeSH terms were used: magnetic resonance imaging, positron-emission tomography, tomography, emission-computed, single photon, and migraine with aura. Additional key words included single photon-emission computed tomography, positron-emission tomography, functional magnetic resonance imaging, magnetic resonance imaging, MRI, SPECT, PET, and migraine aura. The search found 109 papers, and 26 were included in this review paper, although we also hand-searched these references to inform a subsequent literature review. An additional PubMed search with the same MeSH terms and key words was performed without a date range but with the addition of filters to include only clinical trials of all phases, controlled clinical trials, randomized controlled trials, meta-analyses, and systematic reviews. This resulted in an additional 10 papers, four of which were included in this review.