Neuromuscular Block in Patients 80 Years and Older

A Prospective, Controlled Study

Denis Schmartz; Raouf Sghaier; Paul Bernard; Jean Francois Fils; Thomas Fuchs-Buder

Disclosures

BMC Anesthesiol. 2021;21(225) 

In This Article

Results

Thirty five patients were enrolled between May 2020 and March 2021. Data from 3 patients had to be excluded from analysis because of study protocol violation: in 2 patients anesthesia was maintained with sevoflurane instead of propofol and 1 patient received an initial bolus of rocuronium 0.9 mg/kg. Data from 32 patients were complete and could be analyzed.

Of the 32 patients included 16 were ≥ 80 years and 16 were between 20–50 years old. Patients in the group 80+ were 85 years old [82–88] and patients in the group 20–50 were 39 years old [28–42]. The female/male ratio was 4/12 in the group 80+ and 6/10 in the group 20–50. The weight of patients in group 80+ was 70.5 ± 14.0 kg and the BMI was 25.3 ± 3.9. The corresponding values in the group 20–50 were 69.6 ± 10 kg and 24.2 ± 3.9, respectively. Elderly patients had more comorbidities and a higher ASA score than the younger patients (Table 1).

In the group 80+ onset time was 190 ± 46 s and the corresponding value in the group 20–50 was 123 ± 40 s; P < 0.001. The deepest level of neuromuscular block detected was PTC 3.5 and PTC 9, respectively; P = 0.07.

The clinical duration was 52 [48–69.5] min in the group 80+. The corresponding values in the group 20–50 was 36 [34–41] min, respectively; P < 0.001.

Recovery to a TOF-ratio ≥ 0.9 occurred after 77.5 [71–88.5] min and a TOF-ratio ≥ 1.0 was reached after 91.2 [82.2–98] min in the group 80+. The corresponding values in the group 20–50 were 53.5 [49.5–55.5] min and 59.5 [56.5–70.25] min, respectively; P < 0.001.

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