Periodontitis and the Risk of Multimorbidity

Pavankumar Kamat

Disclosures

September 03, 2021

Takeaway

  • Patients with self-reported periodontitis (bleeding and painful gums and loose teeth) were likely to develop multimorbidity earlier and more frequently, which may further increase the risk of mortality.

Why this matters

  • Findings suggest that patients with severe periodontitis should be informed about the potential risks of disease progression and associated multimorbidity, with an emphasis on targeted early prevention initiatives.

Study design

  • UK researchers conducted a prospective cohort study involving 188,863 participants (age, 40-69 years), identified from the UK Biobank (2006-2020).

  • Self-reported oral health indicators (bleeding and painful gums and loose teeth) were used as surrogates for periodontitis.

  • Funding: None.

Key results

  • Of 188,863 participants, 3225 (1.7%) had painful gums, 19,930 (10.6%) had bleeding gums and 3896 (2.1%) had loose teeth.

  • During follow-up, patients with loose teeth vs control group had a higher incidence of systemic disease conditions including (relative risk [RR]; 95% CI):

    • cardiovascular disease (CVD; 1.15; 1.03-1.28);

    • hypertension (1.14; 1.05-1.24);

    • respiratory disease (1.63; 1.40-1.91); and

    • depression (1.33; 1.09-1.61).

  • Patients with painful gums vs control group had a higher incidence of systemic disease conditions including (RR; 95% CI):

    • CVD (1.29; 1.14-1.47); and

    • depression (1.34; 1.09-1.64).

  • Patients with bleeding gums vs control group had a higher incidence of systemic conditions including (RR; 95% CI):

    • hypertension (1.08; 1.02-1.14); and

    • liver disease (1.66; 1.19-2.33).

Limitations

  • Periodontitis indicators were not validated in the UK Biobank population.

 

Larvin H, Kang J, Aggarwal VR, Pavitt S, Wu J. Multimorbid disease trajectories for people with periodontitis. J Clin Periodontol. 2021 Aug 18 [Epub ahead of print]. doi: 10.1111/jcpe.13536. PMID: 34409647.  View abstract 

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.

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