Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019–Related Acute Respiratory Distress Syndrome

A Retrospective Cohort Study

Karuna Wongtangman, MD; Peter Santer, MD, DPhil; Luca J. Wachtendorf; Omid Azimaraghi, MD; Elias Baedorf Kassis, MD; Bijan Teja, MD, MBA; Kadhiresan R. Murugappan, MD; Shahla Siddiqui, MD; Matthias Eikermann, MD, PhD


Crit Care Med. 2021;49(9):1524-1534. 

In This Article


Patients with COVID-19 received higher doses of hypnotics during mechanical ventilation, which was associated with prolonged coma and increased in-hospital mortality. Clinical practices focusing on safely minimizing analgesic and sedative doses and duration of administration should be applied.