Anaphylaxis and Coronavirus Disease 2019 Vaccine: A Danger Relationship?

Luciana Kase Tanno; Mariana Castells; Marco Caminati; Gianenrico Senna; Pascal Demoly


Curr Opin Allergy Clin Immunol. 2021;21(5):411-417. 

In This Article


Vaccines against COVID-19 are an essential global intervention to control the current pandemic situation. Anaphylactic reactions have been reported after severe acute respiratory syndrome coronavirus 2 RNA vaccines. This risk is estimated at 2.5–11/1 000 000 in the context of vaccine safety surveillance programs. The COVID-19 vaccination is rolling out vastly and surveillance programs are key to monitor severe adverse reactions, such as anaphylaxis. Anaphylaxis due to vaccine is extremely rare and specific cases should receive individualized investigation and care. The role of PEG still needs to be proven.