Delta Variant of SARS-CoV-2 'Still Transmissible for Double Jabbed'

Peter Russell

August 19, 2021

Editor's note, 19 August 2021: This article was updated with new information from Public Health England.

Having two doses of a COVID-19 vaccine remains the most effective way of ensuring protection against the Delta variant first identified in India, preliminary research has found.

A preprint study by scientists at the University of Oxford found that both the Pfizer/BioNTech vaccine and the AstraZeneca/Oxford vaccine offered good protection against the Delta variant but that effectiveness was reduced compared with the Alpha variant that was first identified in the UK.

Vaccines Working Differently

Immunity following second doses differed significantly between the two vaccines, the scientists said. There was greater early protection seen in those who had received the Pfizer vaccine but a faster decline in effectiveness compared with those who received the AstraZeneca jab.

The early results suggested that efficacy of the two vaccines would be similar after 4 to 5 months.

Another key finding was that Delta infections after two vaccine doses had similar peak levels of virus to those in unvaccinated people.

Prof Sarah Walker/SMC

Sarah Walker, professor of medical statistics and epidemiology at the University of Oxford, who led the research, said: "We don’t yet know how much transmission can happen from people who get COVID-19 after being vaccinated – for example, they may have high levels of virus for shorter periods of time.

"But the fact that they can have high levels of virus suggests that people who aren't yet vaccinated may not be as protected from the Delta variant as we hoped. This means it is essential for as many people as possible to get vaccinated – both in the UK and worldwide."

The study was based on PCR tests from 384,583 adults during the time when the Alpha variant was predominant, and 358,983 individuals when the Delta variant had taken over.

Scientists did not draw firm conclusions about the Moderna COVID vaccine – the third to be approved for emergency UK use – due to a lack of available evidence. However, they said there was no reason to suppose that it was inferior in any way to the other two vaccines.

'Blunted' Effectiveness

Commenting on the study for the Science Media Centre, Dr Simon Clarke, associate professor in cellular microbiology at the University of Reading, said: "We’re seeing here the real-world data of how two vaccines are performing, rather than clinical trial data, and the data sets all show how the Delta variant has blunted the effectiveness of both the Pfizer and AstraZeneca jabs.

"Of particular concern, the AstraZeneca vaccine's effectiveness is reduced substantially by Delta and it appears to offer no more protection than what someone would get from having COVID-19 and building some natural immunity."

He said that the data "certainly supports the case for third 'booster' jabs for vulnerable individuals".

Dr Penny Ward, visiting professor in pharmaceutical medicine at King's College London, agreed that "a booster dose may be required to sustain effectiveness".

She also suggested that there was "a need for continued focus on test, trace, and isolate activities to reduce the level of spread across the community".

Deaths Prevented

Also published today were the latest estimates from Public Health England on the effects of England's vaccination programme on cases, hospitalisations, and deaths.

It said more than 82,100 hospitalisations had been prevented in people aged 65 and over, 95,200 deaths were prevented, as were 23,957,000 COVID-19 infections.

Health Secretary Sajid Javid said: "The UK’s phenomenal vaccination programme has made a life-changing difference to tens of millions of people across the country, and we’re quickly closing in on 100,000 lives being saved in England alone."

Article image credit: Matthew Horwood/Getty Images

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....