Abrupt-onset, Profound Erectile Dysfunction in a Healthy Young Man After Initiating Over-the-counter Omeprazole

A Case Report

Theodore W. Perry


J Med Case Reports. 2021;15(360) 

In This Article

Case Presentation

A 38-year-old Caucasian man with a history of mild hypertension and who was otherwise healthy [never smoker, body mass index (BMI) 19.6 kg/m2] began taking over-the-counter omeprazole 20 mg daily owing to new-onset gastroesophageal reflux symptoms. One day after initiating therapy (day 2 of therapy), the patient began to notice difficulty obtaining and maintaining an erection despite sustained libido. By day 3 of therapy, the patient was completely unable to obtain an erection. After the fourth day of therapy, the patient suspected the new medication as the culprit and discontinued use. Erectile function then returned to normal over the next several days. The patient had no history of previous ED and in the 2 years following the episode has had no further erectile difficulties. His only other medication was lisinopril 10 mg daily, for which he had been on a stable dose for 11 years. No other medications or supplements were being used.