Progress Toward Hepatitis B Control

World Health Organization European Region, 2016-2019

Nino Khetsuriani, MD, PhD; Liudmila Mosina, MD; Pierre Van Damme, MD, PhD; Antons Mozalevskis, MD; Siddhartha Datta, MD; Rania A. Tohme, MD

Disclosures

Morbidity and Mortality Weekly Report. 2021;70(30):1029-1035. 

In This Article

Antenatal Screening and Postexposure Prophylaxis

The 30 countries that implement a selective HepB-BD policy aim to prevent MTCT of HBV infection through antenatal HBV screening combined with postexposure prophylaxis of infants born to mothers with positive HBsAg test results. Information on implementation of these interventions is not routinely reported to WHO. Based on the responses to a survey conducted by the WHO Regional Office for Europe in 2018§§§ and published reports, 29 (97%) of those 30 countries¶¶¶ conducted nationwide antenatal screening for HBsAg (Table 1). Antenatal screening coverage data were available for 20 (69%) of these countries, and 17 (85%) reported ≥90% coverage.**** Among infants born to HBV-infected mothers in these countries, immunization coverage data were available for HepB-BD in nine (31%) countries†††† and for HepB3 in five (17%)§§§§ countries. HepB-BD coverage exceeded 90% in all nine countries, and HepB3 coverage exceeded 90% in four of five countries.

§§§The survey was sent to the 50 member states of EUR that implement universal HepB vaccination and included questions on HepB vaccination policy, practices, and measures to prevent perinatal transmission of HBV. Survey questions were designed to account for differences in HepB-BD policy between the member states (universal versus selective). Forty-three (86%) countries, including 22 of 23 countries with universal HepB-BD policy and 21 of 30 countries with selective HepB-BD policy, responded to the survey.
¶¶¶Montenegro reported not having nationwide antenatal screening in place.
****Six countries (Czechia, Estonia, France, Greece, Ireland, and Luxembourg) also had ≥90% coverage with routine HepB3 among infants each year during 2017–2019 (i.e., met the validation criteria for immunization).
††††Croatia, Czechia, Denmark, Italy, Malta, the Netherlands, Slovakia, Switzerland, and the United Kingdom. Sources: the 2018 WHO Regional Office for Europe survey (Croatia, Czechia, Malta, Slovakia, and Switzerland); reports submitted to the WHO European Regional Hepatitis B Working Group (the Netherlands and the United Kingdom), https://www.sciencedirect.com/science/article/pii/S0264410X11016355?via%3Dihub (Denmark); https://www.sciencedirect.com/science/article/pii/S0163445310003518?via%3Dihub (Italy).
§§§§Czechia, the Netherlands, Slovakia, Switzerland, and the United Kingdom; coverage was <90% only for Switzerland. Sources: the 2018 WHO Regional Office for Europe survey; reports submitted to the WHO European Regional Hepatitis B Working Group (the Netherlands and the United Kingdom).

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