IAS 2021 — Younger People with HIV Carry an Increased Risk of CVD

Pavankumar Kamat


July 22, 2021


  • People living with HIV (PLWH), especially younger individuals, have an increased risk for mortality, cardiovascular disease (CVD), and cardiovascular (CV) risk factors.

Why this matters

  • The findings emphasise the need for routine screening for CVD and risk factors in younger PLWH.

Study design

  • In a retrospective cohort study using data from The Health Improvement Network (THIN), adults with an HIV diagnosis (exposed, n=9233) were matched for age, sex, and general practice with individuals without HIV (unexposed; n=35,721).

  • The risks for composite CVD, individual components of CVD, CV risk factors, and all-cause mortality were compared between the groups.

  • Funding: None disclosed.

Key results

  • Overall, the exposed vs unexposed group had an increased risk for: 

    • composite CVD (HR, 1.54; 95% CI, 1.30-1.83); 

    • stroke (HR, 1.49; 95% CI, 1.11-2.00);

    • ischaemic heart disease (HR, 1.59; 95% CI, 1.25-2.02);

    • hypertension (HR, 1.37; 95% CI, 1.22-1.55); 

    • use of lipid-lowering drugs (HR, 1.96; 95% CI, 1.78-2.16);

    • chronic kidney disease (HR, 2.40; 95% CI, 1.93-2.98); and 

    • all-cause mortality (HR, 2.68; 95% CI, 2.32-3.10).

  • Younger individuals (age, <40 years) carried a significantly higher risk for: 

    • CVD (HR, 2.01; 95% CI, 1.29-3.13); and 

    • all-cause mortality (HR, 6.09; 95% CI, 4.36-8.51).


  • Findings were not controlled for CD4 count and antiretroviral therapy.

  • Some secondary outcomes and subgroup analyses had wide CIs. 


Gooden T et al. The association of cardiovascular risk factors and disease in people living with HIV in the UK: a retrospective matched cohort study. Oral abstract OAA0103. Presented at the 11th International AIDS Society (IAS) Conference on HIV Science on 18-21 July 2021. 

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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