Serum and Dietary Vitamin D Levels and Metabolic Syndrome in Severely Obese Individuals

Pavankumar Kamat


July 16, 2021


  • Individuals with class II and III obesity (body mass index [BMI], >35 kg/m2) had a low prevalence of vitamin D deficiency.

  • Serum and dietary vitamin D levels were not associated with metabolic syndrome (MS) or its diagnostic parameters, except for low high-density lipoprotein (HDL) cholesterol levels which were associated with serum vitamin D deficiency.

Why this matters

  • The association between vitamin D deficiency and obesity has been evaluated in the scientific literature, but with controversial results.

Study design

  • The study included 150 participants (age, 18-65 years) with class II and III obesity from the DieTBra Trial.

  • Associations between serum and dietary vitamin D and MS or its parameters were evaluated.

  • Funding: Goias State Research Support Foundation.

Key results

  • The prevalence of vitamin D deficiency was 13.3% and the dietary vitamin D median was 51.3 IU/day.

  • In the fully adjusted multivariate regression models, serum and dietary vitamin D were not significantly associated with MS and its parameters, except for lower HDL which was associated with serum vitamin D deficiency (prevalence ratio, 0.71; 95% CI, 0.53-0.97; P=.029).

  • Serum and dietary vitamin D had no significant associations with sociodemographic, lifestyle and anthropometric variables, and the class of obesity.


  • Small sample size.

Silveira EA, Cardoso CKS, Moura LANE, Dos Santos Rodrigues AP, de Oliveira C. Serum and Dietary Vitamin D in Individuals with Class II and III Obesity: Prevalence and Association with Metabolic Syndrome. Nutrients. 2021;13(7). doi: 10.3390/nu13072138. PMID: 34206539.  View full text

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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