Epidemiology of Gallbladder Cancer in the Unites States

A Population-Based Study

Motasem Alkhayyat; Mohannad Abou Saleh; Thabet Qapaja; Mohammad Abureesh; Ashraf Almomani; Emad Mansoor; Prabhleen Chahal


Chin Clin Oncol. 2021;10(3):25 

In This Article


Our study is in agreement with the previous literature in regards to the association of GBC with female sex, older age, gallstone disease, cholecystitis, obesity, diabetes, smoking, alcohol abuse, chronic HBV and HCV infections, family history of GBC, and PSC. This is the largest US study to-date demonstrating incidence rate higher than previously reported. GBC is a rare disease with a poor prognosis. GBC epidemiology is an evolving and is constantly reshaped by several factors including lifestyle, geographic, and diet. The clinician must keep a high index of suspicion of GBC in patients with the risk factors emphasized in this study for timely detection, diagnosis, and better outcomes.