COVID-19 Vaccination Coverage Among Adults

United States, December 14, 2020-May 22, 2021

Jill Diesel, PhD; Natalie Sterrett, MPH; Sharoda Dasgupta, PhD; Jennifer L. Kriss, PhD; Vaughn Barry, PhD; Kayla Vanden Esschert, MPH; Ari Whiteman, PhD; Betsy L. Cadwell, MS; Daniel Weller, PhD; Judith R. Qualters, PhD; LaTreace Harris, MPH; Achal Bhatt, PhD; Charnetta Williams, MD; LeAnne M. Fox, MD; Dana Meaney Delman, MD; Carla L. Black, PhD; Kamil E. Barbour, PhD

Disclosures

Morbidity and Mortality Weekly Report. 2021;70(25):922-927. 

In This Article

Abstract and Introduction

Introduction

The U.S. COVID-19 vaccination program launched on December 14, 2020. The Advisory Committee on Immunization Practices recommended prioritizing COVID-19 vaccination for specific groups of the U.S. population who were at highest risk for COVID-19 hospitalization and death, including adults aged ≥75 years*; implementation varied by state, and eligibility was gradually expanded to persons aged ≥65 years beginning in January 2021. By April 19, 2021, eligibility was expanded to all adults aged ≥18 years nationwide. To assess patterns of COVID-19 vaccination coverage among U.S. adults, CDC analyzed data submitted on vaccinations administered during December 14, 2020–May 22, 2021, by age, sex, and community-level characteristics. By May 22, 2021, 57.0% of persons aged ≥18 years had received ≥1 COVID-19 vaccine dose; coverage was highest among persons aged ≥65 years (80.0%) and lowest among persons aged 18–29 years (38.3%). During the week beginning February 7, 2021, vaccination initiation among adults aged ≥65 years peaked at 8.2%, whereas weekly initiation among other age groups peaked later and at lower levels. During April 19–May 22, 2021, the period following expanded eligibility to all adults, weekly initiation remained <4.0% and decreased for all age groups, including persons aged 18–29 years (3.6% to 1.9%) and 30–49 years (3.5% to 1.7%); based on the current rate of weekly initiation (as of May 22), younger persons will not reach the same levels of coverage as older persons by the end of August. Across all age groups, coverage (≥1 dose) was lower among men compared with women, except among adults aged ≥65 years, and lower among persons living in counties that were less urban, had higher social vulnerabilities, or had higher percentages of social determinants of poor health. Continued efforts to improve vaccination confidence and alleviate barriers to vaccination initiation, especially among adults aged 18–49 years, could improve vaccination coverage.

Vaccination data were reported to CDC via state immunization information systems,§ the Vaccine Administration Management System, or direct data submission to the CDC Data Clearinghouse.** Data for vaccinations administered among adults aged ≥18 during December 14, 2020–May 22, 2021, were included in the analysis.†† Two measures of vaccination coverage were assessed: 1) persons who received ≥1 dose of any COVID-19 vaccine (≥1-dose coverage) authorized by the Food and Drug Administration (FDA) and 2) persons who received 2 doses of an FDA authorized 2-dose vaccine (Pfizer-BioNTech or Moderna) or 1 dose of the Janssen (Johnson & Johnson) vaccine (fully vaccinated); each measure of coverage was calculated using total population counts from the U.S. Census Bureau's 2019 Population Estimates Program.§§ Weekly vaccine initiation was defined as the percentage of persons who received the first dose within the epidemiologic week¶¶ among those in the total population. Coverage (≥1 dose) was projected through the week of August 29, 2021, by applying the rate of weekly initiation in the most recent week (May 22) for each age group to subsequent weeks beyond the study period. Second dose completion was defined as the percentage of persons who received the second dose of a 2-dose vaccine at any point, among those who had received at least 1 dose of a 2-dose vaccine.*** Absolute differences in coverage by age were calculated during three periods selected to represent general shifts in targeted subpopulations, supply, and policy over the course of the COVID-19 vaccination program†††:[1] December 14, 2020–January 23, 2021; January 24, 2021–March 20, 2021; and March 21, 2021–May 22, 2021.

Coverage was evaluated by selected community-level characteristics matched to vaccine recipients' county of residence.§§§ County-level rankings of social vulnerability from the 2018 CDC Social Vulnerability Index (SVI), which is used to identify community needs during emergencies, were categorized into quartiles based on distribution among all U.S. counties.¶¶¶ County-level data on Social Determinants of Health**** obtained from the American Community Survey†††† were dichotomized based on the median of all U.S. counties.§§§§ County-level urbanicity was based on the 2013 National Center for Health Statistics urban-rural classification scheme.¶¶¶¶ Generalized estimating equation models with binomial regression and an identity link were used to estimate absolute differences in coverage and associated 95% confidence intervals. SAS (version 9.4; SAS Institute) was used to conduct all analyses. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.*****

During December 14, 2020–May 22, 2021, 57.0% of U.S. adults had received ≥1 vaccine dose; coverage was highest among adults aged ≥65 years (80.0%) and lowest among adults aged 18–29 years (38.3%) (Figure 1). Vaccination coverage was lower among younger age groups in all states, regardless of timing of expanded vaccine eligibility to all adults (Supplementary Table, https://stacks.cdc.gov/view/cdc/107123). During January 24, 2021–March 20, 2021, coverage among persons aged ≥65 years increased from 14.3% to 67.0% (absolute difference: 52.7%). During March 21, 2021–May 22, 2021, absolute increases in coverage were largest among adults aged 50–64 years (31.5% to 63.5%; absolute difference: 32.0%).

Figure 1.

Trends in COVID-19 vaccination cumulative coverage* and weekly initiation among adults, by epidemiologic week and age group — United States, December 14, 2020–May 22, 2021
*Coverage includes persons who received at least 1 dose of any Food and Drug Administration–authorized COVID-19 vaccine (≥1 dose; Pfizer-BioNTech, Moderna, or Janssen [Johnson & Johnson]).
An epidemiologic week is based on the National Notifiable Diseases Surveillance System guidance and is assigned by the reporting local or state health department for the purposes of MMWR disease incidence reporting and publishing. The first day of any MMWR week is Sunday. https://wwwn.cdc.gov/nndss/document/MMWR_Week_overview.pdf

Over the entire period, weekly initiation was highest among adults aged ≥65 years and peaked during the week of February 7, during which 8.2% of adults aged ≥65 years initiated vaccination (Figure 1). Weekly initiation peaked at 7.5% among adults aged 50–64 years during the week of March 21, at 5.8% among adults aged 30–49 years during the week of April 4, and at 5.3% among adults aged 18–29 years during the week of April 4. Since the week of April 18, during which eligibility was expanded to all adults, weekly COVID-19 vaccine initiation was <4.0% and decreased over time for all age groups, including younger adults aged 18–29 years (3.6% to 1.9%) and 30–49 years (3.5% to 1.7%). If weekly initiation remains at the rate as of the week of May 22 for each age group, coverage by the week of August 29, 2021 is projected to reach 57.5% for adults aged 18–29 years, 71.4% for adults aged 30–49 years, 85.9% for adults aged 50–64 years, 94.9% for adults aged ≥65 years, and 78.4% for persons aged ≥18 years.

By May 22, among adults who initiated a 2-dose vaccine series (Pfizer-BioNTech or Moderna), 89.3% had received their second dose at any point. The second dose completion was similar across age groups (Figure 2) and over time.

Figure 2.

COVID-19 vaccination second dose completion among adults who received ≥1 COVID-19 dose and had sufficient time to receive the second dose,* by age group — United States, December 14, 2020–May 22, 2021
*Analysis for second dose completion was restricted to persons who had received their first dose of a 2-dose vaccine (Pfizer-BioNTech or Moderna) during December 14, 2020–March 31, 2021. All persons included in the analysis for second dose completion were ≥42 days past their first dose.
Excludes residents of Texas because Texas does not report information for age-specific dose number to CDC.

Men had lower coverage than women in all age groups, except those aged ≥65 years (Table). Persons living in counties that were less urban were less likely to be vaccinated, and differences were smaller for adults aged ≥65 years. Across all age groups, people living in counties with higher social vulnerabilities or higher percentages of the population who are uninsured, living in poverty, lacking access to a computer, and lacking access to a computer with Internet were less likely to be vaccinated.

*https://www.cdc.gov/mmwr/volumes/69/wr/mm695152e2.htm
Dates of vaccine eligibility opened to persons aged ≥16 years based on data from the Kaiser Family Foundation State COVID-19 Data and Policy Actions (https://www.kff.org/report-section/state-covid-19-data-and-policy-actions-policy-actions/).
§Immunization information systems are confidential, computerized, population-based systems that collect and consolidate vaccination data from providers in 64 jurisdictions nationwide and can be used to track administered vaccines and measure vaccination coverage. The 64 jurisdictions comprise the 50 U.S. states, five U.S. territories (American Samoa, Guam, Northern Mariana Islands, Puerto Rico, and U.S. Virgin Islands), three freely associated states (Federated States of Micronesia, Marshall Islands, and Palau), and six local jurisdictions (Chicago, Illinois; Houston, Texas; New York, New York; Philadelphia, Pennsylvania; San Antonio, Texas; and Washington, DC).
https://www.cdc.gov/vaccines/covid-19/reporting/vams/program-information.html
**https://www.cdc.gov/vaccines/covid-19/reporting/overview/IT-systems.html
††Vaccination providers are required to report administration records to the state immunization information system within 72 hours; 5 additional days of observation were included to account for delays in reporting and transmission of records to CDC.
§§ https://www.census.gov/programs-surveys/popest.html
¶¶An epidemiologic week is based on the National Notifiable Diseases Surveillance System guidance and is assigned by the reporting local or state health department for the purposes of MMWR disease incidence reporting and publishing. The first day of any MMWR week is Sunday. https://wwwn.cdc.gov/nndss/document/MMWR_Week_overview.pdf
***Analysis for second dose completion was restricted to persons who had received their first dose of a 2-dose vaccine (Pfizer-BioNTech or Moderna) during December 14, 2020–March 31, 2021. All persons included in the analysis for second dose completion were ≥42 days past their first dose.
†††Periods are based on eligibility and other process factors (e.g., phase of vaccine rollout, eligible population, supply, and programs and policy enacted) important in framing the specific needs and constraints at that time. Period 1 represented when most states opened eligibility to health care workers, residents in long-term care facilities, and older adults while there was a highly constrained supply, which overlapped phase 1a, and a portion of phase 1b (https://www.cdc.gov/mmwr/volumes/69/wr/mm695152e2.htm). Period 2 represented when states were expanding eligibility inconsistently, and supply was becoming more available, which overlapped with phases 1b and 1c. Period 3 represented when all states expanded eligibility to all adults while supply was steady and increased, which overlapped with phases 1c and 2.
§§§The following jurisdictions were excluded from all county-level analyses (National Center for Health Statistics urban-rural, SVI, and Social Determinants of Health) due to lack of county-level vaccination data: all counties in Hawaii and eight counties in California for which total population was <20,000. Among all first doses analyzed during December 14, 2020–May 22, 2021, 5.9% were missing county data and were therefore excluded from models.
¶¶¶Fifteen elements categorized into four themes (socioeconomic status, household composition and disability, racial/ethnic minority status and language, and housing type and transportation) are included in SVI (https://www.atsdr.cdc.gov/placeandhealth/svi/documentation/pdf/SVI2018Documentation-H.pdf). Overall SVI includes all 15 indicators as a composite measure (https://www.atsdr.cdc.gov/placeandhealth/svi/fact_sheet/fact_sheet.html). One county in New Mexico was excluded because SVI ranking could not be calculated (https://www.atsdr.cdc.gov/placeandhealth/svi/index.html).
****Measures of Social Determinants of Health from the American Community Survey: percentage of the total population 1) unemployed, 2) uninsured, 3) that earned an income below the federal poverty level, 4) without a computer (e.g., desktop or laptop computer [excludes mobile phones]), 5) with a computer but without Internet access, and 6) identifying as a racial/ethnic group other than non-Hispanic White (https://health.gov/healthypeople/objectives-and-data/social-determinants-health).
†††† https://www.census.gov/programs-surveys/acs
§§§§In some instances, the total non-Hispanic White population exceeded the total population estimate and therefore the model did not permit vaccination initiation estimates to exceed 100%.
¶¶¶¶ https://www.cdc.gov/nchs/data_access/urban_rural.htm#2013_Urban-Rural_Classification_Scheme_for_Counties
*****45 C.F.R. part 46, 21 C.F.R. part 56; 42 U.S.C. Sect. 241(d); 5 U.S.C. Sect. 552a; 44 U.S.C. Sect. 3501 et seq.

Comments

3090D553-9492-4563-8681-AD288FA52ACE

processing....