Sleep Disturbances and Diabetes Linked to an Increased Mortality Risk

Pavankumar Kamat

Disclosures

June 25, 2021

Takeaway

  • Frequent sleep disturbances were associated with an increased risk of all-cause mortality.

  • The risk was pronounced in patients with diabetes and frequent sleep disturbances compared with those with diabetes without frequent sleep disturbances.

Why this matters

  • Patients with diabetes generally have poorer sleep quality which has been linked to worse glycaemic control.

  • Whether the combination of diabetes and frequent sleep disturbances influences mortality risk has not been previously investigated.

Study design

  • A study of 487,728 participants (mean follow-up time, 8.9 years) from the UK Biobank.

  • Primary outcomes: all-cause and cardiovascular disease (CVD) mortality.

  • Funding: US National Institutes of Health and others.

Key results

  • During the mean follow-up period of 8.9 years, 19,177 deaths from all causes and 3874 deaths from CVD were reported.

  • Overall, 118,217 (24.2%) participants “never/rarely”  experienced sleep disturbances, 233,177 (47.8%) experienced sleep disturbances “sometimes” and 136,334 (28.0%) “usually” experienced sleep disturbances.

  • In age- and sex-adjusted models, frequent sleep disturbances were linked to an increased risk of all-cause mortality (adjusted HR [aHR], 1.31; 95% CI, 1.26-1.37), which remained significant in the fully adjusted model (aHR, 1.13; 95% CI, 1.09-1.18).

  • In age- and sex-adjusted models, frequent sleep disturbances were significantly associated with an increased risk of CVD mortality (aHR, 1.33; 95% CI, 1.22-1.44), but this association did not remain significant in the fully adjusted models (aHR, 1.02; 95% CI, 0.93-1.12).

  • Both diabetes and frequent sleep disturbances vs diabetes alone were associated with a greater risk of all-cause mortality (aHR, 1.12; 95% CI, 1.04-1.22).

  • In the fully adjusted model, the risk of all-cause mortality increased with (aHR; 95% CI):

    • frequent sleep disturbances (1.11; 1.07-1.15);

    • diabetes (1.67; 1.57-1.76); and

    • diabetes and frequent sleep disturbances (1.87; 1.75-2.01).

Limitations

  • Results may have limited generalisability. 
     

 

von Schantz M, Ong JC, Knutson KL. Associations between sleep disturbances, diabetes and mortality in the UK Biobank cohort: A prospective population-based study. J Sleep Res. 2021 Jun 08 [Epub ahead of print]:e13392. doi: 10.1111/jsr.13392. PMID: 34101927.  View full text

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.

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