How I Diagnose Angioimmunoblastic T-Cell Lymphoma

Yi Xie, MD, PhD; Elaine S. Jaffe, MD


Am J Clin Pathol. 2021;156(1):1-14. 

In This Article

Other Nodal Peripheral T-cell Lymphoma With TFH Phenotype

In addition to AITL, the 2016 revised WHO classification included two provisional entities of PTCL-TFH, namely, FTCL and nodal PTCL with a TFH phenotype. In FTCL, lymph nodes typically show a predominantly nodular/follicular growth pattern, mimicking follicular lymphoma. The neoplastic T cells tend to form small aggregates dispersed in the B-cell nodules.[12] These lesions may contain EBV-positive or EBV-negative HRS-like cells but usually do not have a prominent inflammatory background and lack proliferation of HEVs or extrafollicular expansion of FDC meshworks.[46] Despite morphologic differences, the immunophenotypic and molecular features overlap with AITL.[11] Furthermore, there are a few reports of patients with typical features of AITL at initial presentation but FTCL in subsequent biopsy specimens or vice versa, suggesting that these entities may represent variations along the spectrum of a common disease.[12]